Original StudyRETINAL STRUCTURAL ALTERATIONS AND MACULAR SENSITIVITY IN IDIOPATHIC MACULAR TELANGIECTASIA TYPE 1Takayama, Kohei MD; Ooto, Sotaro MD; Tamura, Hiroshi MD; Yamashiro, Kenji MD; Otani, Atsushi MD; Tsujikawa, Akitaka MD; Yoshimura, Nagahisa MDAuthor Information Department of Ophthalmology and Visual Sciences, Kyoto University Graduate School of Medicine, Kyoto, Japan. Reprint requests: Sotaro Ooto, MD, Department of Ophthalmology and Visual Sciences, Kyoto University Graduate School of Medicine, 54 Kawahara-cho, Shogoin, Sakyo-ku, Kyoto 606-8507, Japan; e-mail: [email protected] Supported in part by a Grant-in-Aid for Scientific Research (21791679) from the Japan Society for the Promotion of Science. No author has any financial/conflicting interests to disclose. Retina: October 2012 - Volume 32 - Issue 9 - p 1973-1980 doi: 10.1097/IAE.0b013e318251a38b Buy Metrics AbstractIn Brief Purpose: To evaluate the relationship between the abnormalities of retinal structures showed on spectral-domain optical coherence tomography and the changes in the macular sensitivity measured by microperimetry in eyes with idiopathic macular telangiectasia type 1. Methods: Eleven eyes of 11 patients with macular telangiectasia type 1 were reviewed. Morphologic changes in the retina and retinal sensitivity of eyes with macular telangiectasia type 1 were studied using spectral-domain optical coherence tomography and microperimetry. Results: Spectral-domain optical coherence tomographic images revealed disruptions in the photoreceptor inner segment–outer segment (IS/OS) junction in all the eyes and intraretinal cystoid spaces in 10 eyes. In the points that had intraretinal cystoid spaces, the mean retinal sensitivity was 6.8 ± 5.5 dB where the IS/OS was disrupted and 13.4 ± 4.0 dB where the IS/OS was intact (P < 0.001). In the points that had intact IS/OS and no cystoid spaces, the mean retinal sensitivity was 15.3 ± 4.3 dB, which was better than that of points that had intact IS/OS with cystoid spaces (P < 0.001). Conclusion: Retinal sensitivity is influenced not only by intraretinal cystoid spaces but also by IS/OS disruptions, and the IS/OS alterations reduce the visual function more severely. We evaluated the relationship between retinal structures and macular sensitivity in eyes with idiopathic macular telangiectasia type 1. Retinal sensitivity is influenced not only by intraretinal cystoid spaces but also by photoreceptor disruptions, and the photoreceptor alterations reduce the visual function more severely. © The Ophthalmic Communications Society, Inc.