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COMBINED INTRAVITREAL RANIBIZUMAB AND PHOTODYNAMIC THERAPY FOR POLYPOIDAL CHOROIDAL VASCULOPATHY

Saito, Masaaki MD; Iida, Tomohiro MD; Kano, Mariko MD

doi: 10.1097/IAE.0b013e318236e624
Original Study

Purpose: To clarify the efficacy of combined therapy with intravitreal ranibizumab injections and photodynamic therapy in patients with symptomatic polypoidal choroidal vasculopathy.

Methods: We retrospectively reviewed 28 naive eyes of 28 patients (17 men, 11 women; mean age, 73.4 years; range, 55–85 years) with 20/40 or less baseline visual acuity treated with 3 consecutive monthly intravitreal injections of ranibizumab (0.5 mg/0.05 mL) and photodynamic therapy and followed-up for at least 12 months. Photodynamic therapy was administered 1 day or 2 days after the initial injection of ranibizumab.

Results: The mean best-corrected visual acuity levels significantly (P < 0.0001) improved from 0.33 at baseline to 0.61 at 12 months. The mean improvement in best-corrected visual acuity 12 months from baseline was 2.65 lines. The best-corrected visual acuity at 12 months improved in 15 eyes (53.6%) by ≥3 lines and was stable (defined as a loss of <3 lines of vision) in 13 eyes (46.4%). The central retinal thickness significantly (P < 0.0001) decreased from 366 µm to 151 µm at 12 months. The mean numbers of photodynamic therapy treatments and injections during 12 months including the treatments during the initial regimen were 1.1 and 3.7, respectively. No complications developed.

Conclusion: Combined intravitreal ranibizumab and photodynamic therapy for polypoidal choroidal vasculopathy maintained or improved visual acuity and reduced the exudation without adverse events.

This study shows that combined therapy with intravitreal ranibizumab injections and photodynamic therapy was effective for maintaining or improving visual acuity and the anatomic changes in 28 naive eyes of 28 patients with symptomatic polypoidal choroidal vasculopathy without adverse events over 12 months (mean numbers, 1.1 photodynamic therapy, 3.7 injections).

Department of Ophthalmology, Fukushima Medical University School of Medicine, Fukushima, Japan.

Reprint requests: Masaaki Saito, MD, Department of Ophthalmology, Fukushima Medical University School of Medicine, 1 Hikarigaoka, Fukushima 960-1295, Japan; e-mail: smasaaki@fmu.ac.jp).

The authors declare no conflict of interest.

© The Ophthalmic Communications Society, Inc.