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Almony, Arghavan MD*; Nudleman, Eric MD, PhD; Shah, Gaurav K. MD†,‡; Blinder, Kevin J. MD†,‡; Eliott, Dean B. MD§; Mittra, Robert A. MD; Tewari, Asheesh MD**

doi: 10.1097/IAE.0b013e318227ab39
Original Study

Background: The internal limiting membrane represents the structural interface between the retina and the vitreous and has been postulated to serve several essential functions. Recently, internal limiting membrane peeling has been used in the treatment of a variety of retinal disorders. We review the history, techniques, rationale, and outcomes of internal limiting membrane peeling.

Methods: A review of the literature.

Results: Internal limiting membrane peeling has been used to successfully treat a variety of retinal disorders including macular hole, epiretinal membrane, diabetic macular edema, retinal vein occlusion, and others.

Conclusion: Internal limiting membrane peeling may serve as an important component in the armamentarium of retinal surgery.

*Department of Ophthalmology, University of Missouri-Columbia, Columbia, Missouri

Department of Ophthalmology and Visual Sciences, Washington University School of Medicine, St. Louis, Missouri

Barnes Retina Institute, St. Louis, Missouri

§Doheny Eye Institute, Los Angeles, California

VitreoRetinal Surgery, PA Minneapolis, Minnesota

**Kresge Eye Institute, Detroit, Michigan.

Supported in part by a Heed Foundation Fellowship.

The authors have no proprietary interest in the material presented.

Reprint requests: Gaurav K. Shah, MD, Barnes Retina Institute, 1600 South Brentwood Boulevard, Suite 800, St. Louis, Missouri 63144; e-mail:

© The Ophthalmic Communications Society, Inc.