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CHARACTERISTICS OF OPTICAL COHERENCE TOMOGRAPHIC HYPERREFLECTIVE FOCI IN RETINAL VEIN OCCLUSION

Ogino, Ken MD; Murakami, Tomoaki MD, PhD; Tsujikawa, Akitaka MD, PhD; Miyamoto, Kazuaki MD, PhD; Sakamoto, Atsushi MD, PhD; Ota, Masafumi MD, PhD; Yoshimura, Nagahisa MD, PhD

doi: 10.1097/IAE.0b013e318217ffc7
Original Study
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Purpose: To evaluate the hyperreflective foci in branch retinal vein occlusion and central retinal vein occlusion depicted by spectral-domain optical coherence tomography (OCT).

Methods: Consecutive series of 73 eyes of 73 patients with retinal vein occlusion (58 branch retinal vein occlusion and 15 central retinal vein occlusion) who had Spectralis OCT images obtained were retrospectively reviewed, comparing color fundus photographs and fluorescein angiography.

Results: Hyperreflective foci were detected in 54 eyes (74.0%) by spectral-domain OCT, and hard exudates were detected in 17 eyes (23.3%) by color fundus photography. Hard exudates on the color photographs corresponded to the confluence of hyperreflective foci mainly around the outer plexiform layer in the unaffected areas on the spectral-domain OCT images, whereas fine hyperreflective foci were scattered in all retinal layers of the affected areas (P < 0.001). Most eyes with hyperreflective foci attached to the inner side of the external limiting membrane also had serous retinal detachment (P < 0.001). Compared with diabetic macular edema, we did not find subfoveal hard exudates in retinal vein occlusion.

Conclusion: Hyperreflective foci delineated on spectral-domain OCT suggest the pathogenesis regarding the flow of extravasated blood constituents in retinal vein occlusion.

Seventy-three eyes with macular edema associated with retinal vein occlusion were retrospectively evaluated. Hyperreflective foci delineated by Spectralis optical coherence tomography were accumulated in outer plexiform layer in the unaffected area, compared with their scattering in the affected area. They were also attached to the inner side of external limiting membrane especially in eyes with serous retinal detachments.

From the Department of Ophthalmology and Visual Sciences, Kyoto University Graduate School of Medicine, Sakyo, Kyoto, Japan.

The authors have no financial or conflicts of interest to disclose.

Reprint requests: Tomoaki Murakami, MD, PhD, Department of Ophthalmology and Visual Sciences, Kyoto University Graduate School of Medicine, 54 Shogoin-Kawaracho, Sakyo, Kyoto 606-8507, Japan;e-mail: mutomo@kuhp.kyoto-u.ac.jp

© The Ophthalmic Communications Society, Inc.