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TREATMENT OF MACULAR EDEMA BECAUSE OF OCCLUSIVE VASCULITIS WITH BEVACIZUMAB (AVASTIN): Efficacy of Three Consecutive Monthly Injections

Nuti, Elisabetta MD; Traversi, Claudio MD; Marigliani, Davide MD; Balestrazzi, Angelo MD; Alegente, Marco MD; Martone, Gianluca MD; Malandrini, Alex MD; Romeo, Napoleone MD; Mazzotta, Cosimo MD; Tosi, Gian Marco MD

doi: 10.1097/IAE.0b013e318219de8b
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Purpose: To report the efficacy of intravitreal bevacizumab, administered in a series of three monthly injections followed by a period of observation, in the treatment of cystoid macular edema because of occlusive vasculitis.

Methods: This is a retrospective review of 13 consecutive eyes of 13 patients with cystoid macular edema because of occlusive vasculitis, which had been unresponsive to other medications and were treated with intravitreal bevacizumab (1.25 mg). The evaluation consisted of a complete ophthalmologic examination, including best-corrected visual acuity measurement, ophthalmoscopy, fluorescein angiography, and optical coherence tomography. The eyes received a series of 3 monthly injections followed by a 3-month observation period.

Results: A significant improvement in foveal thickness and visual acuity was obtained after the first injection, which increased after the second and the third injections and was maintained for 1.5 months after the last injection. The 2 parameters returned to the baseline values 3 months after the last treatment. There were no ocular or systemic adverse effects.

Conclusion: Intravitreal injection of bevacizumab seems to be well tolerated and is associated with short-term improvement of visual acuity and decreased retinal thickness in patients with cystoid macular edema because of vasculitis that is resistant to conventional therapy.

From the Department of Ophthalmology and Neurosurgery, University of Siena, Siena, Italy.

The authors have no financial interest or conflicts of interest.

Reprint requests: Gian Marco Tosi, MD, Department of Ophthalmology and Neurosurgery, University of Siena, Viale Bracci # 1, 53100 Siena, Italy; e-mail: gmtosi@tin.it

© The Ophthalmic Communications Society, Inc.