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SUBFOVEAL CHOROIDAL THICKNESS AFTER TREATMENT OF VOGT–KOYANAGI–HARADA DISEASE

Maruko, Ichiro MD*; Iida, Tomohiro MD*; Sugano, Yukinori MD*; Oyamada, Hiroshi MD*; Sekiryu, Tetsuju MD*; Fujiwara, Takamitsu MD; Spaide, Richard F MD

doi: 10.1097/IAE.0b013e3181eef053
Original Study
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Purpose: To evaluate the subfoveal choroidal thickness in Vogt-Koyanagi-Harada (VKH) disease using enhanced depth imaging optical coherence tomography.

Methods: Retrospective observational study. Subfoveal choroidal thickness was measured using enhanced depth imaging optical coherence tomography, in which the optical coherence tomography instrument was placed close enough to the eye to obtain an inverted image, which was averaged for 100 scans. All patients were diagnosed as having the ocular findings of VKH disease with or without extraocular disorders. The patients were followed during their initial treatment with corticosteroids.

Results: All 8 patients (16 eyes) with acute phase VKH disease presented with thickening of the choroid. The serous retinal detachment disappeared in 1 month after corticosteroid treatment. The mean choroidal thickness in 16 eyes decreased from 805 ± 173 μm at the first visit to 524 ± 151 μm at 3 days (P < 0.001) and 341 ± 70 μm by 2 weeks (P < 0.001).

Conclusion: Patients with active VKH disease have markedly thickened choroids, possibly related not only to inflammatory infiltration but also to increased exudation. Both the choroidal thickness and the exudative retinal detachment decreased quickly with corticosteroid treatment. Enhanced depth imaging optical coherence tomography can be used to evaluate the choroidal involvement in VKH disease in the acute stages and may prove useful in the diagnosis and management of this disease noninvasively.

The acute stage of Vogt-Koyanagi-Harada disease showed marked choroidal thickening and decreased dramatically after corticosteroid therapy on enhanced depth imaging optical coherence tomography technique, which might prove useful in the diagnosis and management of this disease noninvasively.

From the *Department of Ophthalmology, School of Medicine, Fukushima Medical University, Fukushima, Japan; †Department of Ophthalmology, School of Medicine, Iwate Medical University, Morioka, Japan; and ‡Vitreous Retina Macula Consultants of New York, New York, New York.

The authors have no proprietary or commercial interest in any materials discussed in this article.

Reprint requests: Ichiro Maruko, MD, Department of Ophthalmology, School of Medicine, Fukushima Medical University, 1 Hikarigaoka, Fukushima, 960-1295, Japan; e-mail: imaruko@fmu.ac.jp

© The Ophthalmic Communications Society, Inc.