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Lumbroso, Bruno MD*; Savastano, Maria Cristina MD; Rispoli, Marco MD; Balestrazzi, Angelo PhD§; Savastano, Alfonso MD; Balestrazzi, Emilio MD

doi: 10.1097/IAE.0b013e3181eef3eb
Original Study

Purpose: To assess morphologic differences in pigment epithelial detachment (PED) with en face optical coherence tomography in central serous chorioretinopathy (CSC) and age-related macular degeneration (AMD).

Methods: We recruited 30 eyes of 22 patients with PED. Nine eyes had a clinical diagnosis of CSC and 21 had AMD. All patients were assessed with en face optical coherence tomography. Morphologic PED aspects were estimated on C-scans and classified according to shape, inner silhouette, content, wall aspects, wall thickness, and size.

Results: Pigment epithelial detachment shape was predominantly circular (88.8%) in CSC and irregular or with multilobular features in AMD (76.2%). The PED inner silhouette had a smooth aspect (88.9%) in CSC and a slightly granular aspect or granular profile in AMD (100%). Clear PED content was the most characteristic feature of CSC (88.9%) but not of AMD. In CSC, PED morphologic wall aspect was uniform or slightly irregular (100%), while in AMD, it was slightly irregular (52.4%) or irregular (47.6%). Pigment epithelial detachment wall thickness and dimensions were larger in AMD than in CSC. Statistically significant differences were observed between CSC and AMD concerning PED inner silhouette, contents, wall aspects, and wall thickness measurements.

Conclusion: En face optical coherence tomography scanning is a valuable tool for showing important morphologic differences between CSC and AMD.

The aim of this study was to assess retinal pigment epithelial detachment, a condition associated with multiple macular diseases, with en face optical coherence tomography transverse scans, particularly showing the different morphologic characteristics between age-related macular degeneration and central serous chorioretinopathy.

From the *“Mediterranean Ophthalmology Center,” Rome, Italy; †Department of Ophthalmology, Catholic University “Sacro Cuore” Policlinic “A. Gemelli,” Rome, Italy; ‡Ophthalmology Hospital, “George Eastman,” Rome, Italy; §Department of Ophthalmology, “Santa Maria alle Scotte,” University of Siena, Siena, Italy; and ¶Institute of Ophthalmology, “SUN” Naples, Italy.

B. Lumbroso and M. C. Savastano contributed equally to this article.

The authors have no proprietary or financial interest in any material or device mentioned.

Reprint requests: Bruno Lumbroso, MD, “Centro Oftalmologico Mediterraneo,” via A. Brofferio 7, 00195 Rome, Italy; e-mail:

© The Ophthalmic Communications Society, Inc.