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Ho, Vincent BS*; Ho, Lawrence Y MD; Ranchod, Tushar M MD; Drenser, Kimberly A MD, PhD; Williams, George A MD; Garretson, Bruce R MD

doi: 10.1097/IAE.0b013e3181ecccf0
Original Study

Purpose: To report on the presentation, treatment, and outcomes of the largest series to date for patients with endogenous methicillin-resistant Staphylococcus aureus endophthalmitis at a single institution and compare the results from previously published reports of this disease entity.

Methods: Retrospective, noncomparative, consecutive case series of patients who were treated for endogenous methicillin-resistant S. aureus endophthalmitis from a single tertiary referral institution were reviewed.

Results: Eight eyes of seven consecutive patients, with a mean age of 58.1 years, were diagnosed with culture-proven endogenous methicillin-resistant S. aureus endophthalmitis. Five patients were male, and six patients had a unilateral presentation. Five of eight eyes were treated with initial vitreous tap and injection of antibiotics, and six eyes showed a retinal detachment during the course of treatment. Final visual acuity ranged from 20/40 to no light perception, and 5 of 8 eyes showed improvement in visual acuity from initial presentation. Only one eye became blind and painful and required enucleation.

Conclusion: This series represents the largest single-institution report on endogenous methicillin-resistant S. aureus endophthalmitis and associated outcomes. Although previously reported cases cited poor visual outcomes and high enucleation rates, the authors' current series shows that retinal detachments are common and enucleation rates are low.

Endogenous methicillin-resistant Staphylococcus aureus endophthalmitis is an entity that is increasing in prevalence and has traditionally been associated with poor visual outcomes. This series from a single institution shows that retinal detachments are a common complication, but with proper management, enucleation rates are low.

From *The Ohio State University College of Medicine, Columbus, Ohio; and the †Beaumont Eye Institute, Associated Retinal Consultants, Royal Oak, Michigan.

This manuscript has not been published elsewhere nor been submitted simultaneously for publication elsewhere.

The authors report no conflicts of interest.

Reprint requests: Lawrence Y. Ho, MD, Beaumont Eye Institute, Associated Retinal Consultants, 3535 W. Thirteen Mile Road, Suite #344, Royal Oak, MI 48073; e-mail:

© The Ophthalmic Communications Society, Inc.