SUPRASELECTIVE INJECTION OF INTRAARTERIAL MELPHALAN AS THE PRIMARY TREATMENT FOR LATE PRESENTATION UNILATERAL MULTIFOCAL STAGE VB RETINOBLASTOMA

Abstract

Purpose: 

The purpose of this study was to report a case of a 7-year-old girl with unilateral, multifocal Reese Ellsworth Stage Vb retinoblastoma who was successfully treated using intraarterial chemotherapy infusion as the primary therapy.

Methods: 

This is an interventional case report. A 7-year-old girl presented with advanced unilateral retinoblastoma. The patient received intraarterial melphalan infusion therapy as the primary treatment.

Results: 

Complete tumor resolution was seen at 1 month after intraarterial melphalan infusion.

Conclusion: 

This case of advanced retinoblastoma in a 7-year-old girl was successfully treated with intraarterial melphalan infusion alone. Treatment resulted in complete resolution of the tumor 1 month after treatment. In comparison with systemic chemotherapy, intraarterial melphalan infusion therapy may be a less toxic and more effective primary treatment option in the future management of advanced retinoblastoma.

In Brief

A 7-year-old girl presented with unilateral, multifocal advanced retinoblastoma and was administered intraarterial melphalan infusion as primary treatment. The tumor showed complete resolution 1 month after treatment without need for systemic chemotherapy, enucleation, or radiation. The clinical course and treatment of tumors were documented with fundus photography and echography.