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BEVACIZUMAB COMPARED WITH MACULAR LASER GRID PHOTOCOAGULATION FOR CYSTOID MACULAR EDEMA IN BRANCH RETINAL VEIN OCCLUSION

RUSSO, VINCENZO MD, PhD; BARONE, ANTONIO MD; CONTE, EMANUELE MD; PRASCINA, FRANCESCO MD; STELLA, ANDREA MD; NOCI, NICOLA DELLE MD

doi: 10.1097/IAE.0b013e318195ca65
Original Articles

Introduction: To evaluate the outcome of cystoid macular edema treated with intravitreal injections of bevacizumab and macular grid laser photocoagulation (GLP), in patients with perfused branch retinal vein occlusion.

Methods: Thirty eyes of 30 consecutive patients with cystoid macular edema secondary to nonischemic branch retinal vein occlusion were assigned to either GLP group or to intravitreal bevacizumab (IB) group. Complete ophthalmologic examinations were performed just before GLP and IB injection at 1, 3, 6, and 12 months after treatment. Changes in logarithm of minimum angle of resolution (logMAR) best-corrected visual acuity (BCVA), central macular thickness (CMT) shown by optical coherence tomography-3 were evaluated.

Results: Baseline BCVA (logMAR) and CMT were, respectively, 0.89 ± 0.13 and 650 ± 140 μm for the GLP group, 0.87 ± 0.16 and 690 ± 120 μm for the IB group. After the treatment, at 1, 3, 6, and 12 months in the GLP group, BCVA had improved by 0.19, 0.22, 0.21, and 0.20 logMAR, CMT had decreased by 40%, 41.3%, 40.5%, and 42%. In the IB group, BCVA had improved by 0.31, 0.32, 0.30, and 0.31 logMAR and CMT had decreased by 59.5%, 59%, 60%, and 60.3%. The group receiving bevacizumab had better BCVA and lower CMT values at all time points (P < 0.05).

Conclusion: Intravitreal bevacizumab injection improves BCVA and reduces CMT more than GLP. Intravitreal bevacizumab injection was well tolerated and could be used as primary treatment in patients with cystoid macular edema secondary to perfused branch retinal vein occlusion.

This manuscript describes 30 eyes of 30 consecutive patients with cystoid macular edema secondary to nonischemic branch retinal vein occlusion treated with macular grid laser photocoagulation or intravitreal bevacizumab injections.

From the Department of Ophthalmology, Policlinico di Foggia, University of Foggia, Foggia, Italy.

The authors have no proprietary interest in the materials used in this study.

Reprint requests: Dr. Antonio Barone, MD, Ospedali Riuniti di Foggia, Viale Pinto, 1, 71100, Foggia, Italy; e-mail: antoniobarone79@yahoo.it

© 2009 by Ophthalmic Communications Society, Inc.