Original ArticlesFUNDUS AUTOFLUORESCENCE AND MULTIPLE EVANESCENT WHITE DOT SYNDROMEFURINO, CLAUDIO MD; BOSCIA, FRANCESCO MD; CARDASCIA, NICOLA MD; ALESSIO, GIOVANNI MD; SBORGIA, CARLO MDAuthor Information From the Dipartimento di Oftalmologia ed Otorinolaringoiatria, Università di Bari, Bari, Italy. No author has a proprietary interest. No conflicting relationship exists for any author. Reprint requests: Dr. Francesco Boscia, MD, Dipartimento di Oftalmologia ed Otorinolaringoiatria-Università di Bari, Piazza Giulio Cesare, 11, 70124 Bari, Italy; e-mail: [email protected] Retina: January 2009 - Volume 29 - Issue 1 - p 60-63 doi: 10.1097/IAE.0b013e31818c5e04 Buy Metrics AbstractIn Brief Objective: To describe fundus autofluorescence (FAF) in a series of patients with multiple evanescent white dot syndrome. Methods: Three eyes of three patients with multiple evanescent white dot syndrome were evaluated with indocyanine green angiography and FAF imaging to evaluate the correspondence between FAF and ICG patterns and the nature of the focal hypocyanescent spots evident with ICG. Results: In the acute phase, all three eyes showed increased autofluorescence area corresponding precisely to the site of the focal hypocyanescent spots seen on ICG but less numerous. After 2 months, mean best-corrected visual acuity improved from 20/38 to 20/20 and FAF and indocyanine green angiography returned to normal pattern. Discussion: FAF is an useful noninvasive diagnostic adjunct to identify multiple evanescent white dot syndrome, suggesting the inflammatory nature of the disease, probably due to perturbation of the photoreceptor-retinal pigment epithelium complex affecting the function of these cells. Autofluorescence fundus imaging may help the interpretation of angiographic patterns of multiple evanescent multiple evanescent white dot syndrome allowing the understanding of the inflammatory nature of the disease. © The Ophthalmic Communications Society, Inc.