Secondary Logo

Journal Logo

Institutional members access full text with Ovid®

COMBINED PHOTODYNAMIC THERAPY WITH VERTEPORFIN AND INTRAVITREAL BEVACIZUMAB FOR CHOROIDAL NEOVASCULARIZATION IN AGE-RELATED MACULAR DEGENERATION

DHALLA, MANDEEP S. MD*†; SHAH, GAURAV K. MD*†; BLINDER, KEVIN J. MD*†; RYAN, EDWIN H. JR MD; MITTRA, ROBERT A. MD; TEWARI, ASHEESH MD*†

doi: 10.1097/01.iae.0000247164.70376.91
Original Articles
Buy

Purpose: To examine the 7-month results for patients treated with combined photodynamic therapy (PDT) with verteporfin and intravitreal bevacizumab for choroidal neovascularization (CNV) secondary to age-related macular degeneration (AMD).

Methods: This is a retrospective series of 24 eyes with juxtafoveal or subfoveal CNV secondary to AMD. Patients were treated with PDT with verteporfin and 1.25 mg of intravitreal bevacizumab. All patients were naive to treatment and had either treatment within a 14-day interval. Main outcome measures were visual acuity stabilization (defined as no change or a gain in visual acuity) and retreatment rate.

Results: At the 7-month follow-up, 20 (83%) of 24 patients had stabilization of visual acuity. Sixteen eyes (67%) had improvement in visual acuity. Mean improvement in visual acuity (n = 24) was 2.04 Snellen lines. Fifteen eyes (63%) required only a single combined treatment for CNV resolution. There were no complications, including endophthalmitis, uveitis, and ocular hypertension.

Conclusion: The results of this study suggest that combined treatment of PDT with verteporfin and intravitreal bevacizumab may be useful in treating neovascular AMD by reducing retreatment rates and improving visual acuity. Further investigation with large, controlled trials is warranted to outline the appropriate treatment paradigm for combination therapy.

Mean improvement in vision of 2.04 lines, and in 63% of patients requiring only a single treatment of combined PDT with verteporfin and intravitreal bevacizumab, affirms the need for further investigation of combination treatment of neovascular AMD.

From *Barnes Retina Institute, St. Louis, Missouri; †Department of Ophthalmology, Washington University School of Medicine, St. Louis, Missouri; and ‡Vitreoretinal Surgery, PA, Edina, MN.

The authors have no proprietary interest in this article.

Reprint requests: Gaurav K. Shah, MD, 1600 South Brentwood Boulevard, Suite 800, St. Louis, MO 63144; e-mail: gkshah1@gmail.com

© The Ophthalmic Communications Society, Inc.