To evaluate the prevalence of moderate fasting hyperhomocysteinemia (HHcy) and postmethionine load (PML) HHcy among patients with early-onset central retinal vein occlusion (CRVO).
The prevalence of fasting HHcy and that of PML HHcy were evaluated in a consecutive series of 58 patients with CRVO who were younger than 56 years of age (mean age, 40.3 years) and in 103 controls (mean age, 39.6 years). Plasma folate, vitamin B12, and pyridoxal-5′-phosphate (PLP) levels were measured in 42 patients and 67 controls.
Mantel–Haenszel odds ratios for CRVO patients were 3.00 (95% confidence interval [CI], 0.83–10.8) for fasting HHcy, 3.50 (95% CI, 1.07–11.4) for PML HHcy, and 3.00 (1.18–7.6) for fasting HHcy and PML HHcy in subjects with normal fasting total homocysteine (tHcy) levels. Moderate HHcy was associated with reduced plasma levels of folate and PLP (P ≤ 0.04). There was no significant dependence of fasting and PML tHcy levels on any traditional risk factor evaluated.
Moderate HHcy is an independent risk factor for early-onset CRVO.
Moderate hyperhomocysteinemia (HHcy) is an independent risk factor for central retinal vein occlusion (CRVO) in patients younger than 56 years.
From *Department of Ophthalmology & Visual Sciences and †Department of Coagulation Service & Thrombosis Research Unit, University Hospital S. Raffaele, Milan, Italy.
Supported in part by a grant from the Italian Ministry of Health “Ricerca Finalizzata 2003: Omocisteina e rischio vascolare: fattori ambientali e genetici e controllo terapeutico.”
The authors have no proprietary interest in any of the materials used in this study.
Reprint requests: Rosangela Lattanzio, MD, Department of Ophthalmology & Visual Sciences, University Hospital S. Raffaele, Via Olgettina 60, Milano 20132, Italy; e-mail: firstname.lastname@example.org