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ACUTE CENTRAL SEROUS CHORIORETINOPATHY AND FUNDUS AUTOFLUORESCENCE

EANDI, CHIARA M. MD; OBER, MICHAEL MD; IRANMANESH, REZA MD; PEIRETTI, ENRICO MD; YANNUZZI, LAWRENCE A. MD

Original Articles
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Objectives: To describe fundus autofluorescence (FAF) in a series of patients with acute central serous chorioretinopathy (CSC).

Methods: Nine eyes of six patients with acute CSC were evaluated with fluorescein angiography (FA) and FAF imaging to evaluate the nature of the focal retinal pigment epithelial (RPE) leak evident with FA.

Results: All nine eyes in this series demonstrated hypoautofluorescence corresponding precisely to the site of the focal RPE leak seen on FA.

Conclusions: In this group of patients, the acute focal RPE leaks seen with FA corresponded precisely to an area of hypoautofluorescence imaged with FAF. This observation supports the concept that a mechanical defect or absence of the RPE accounts for the leakage from the inner choroid to the subneurosensory space in CSC. FAF is also a useful noninvasive diagnostic adjunct to identify the focal RPE leak in patients with acute CSC.

Fundus autofluorescence is a noninvasive imaging technique useful in identifying a focal retinal pigment epithelium leak in acute central serous chorioretinopathy.

From *The LuEsther T. Mertz Retina Research Center of Manhattan Eye, Ear and Throat Hospital, New York, and Vitreous-Retina-Macula Consultants of New York, New York; and

†Department of Clinical Physiopathology, Eye Clinic, University of Torino, Italy.

Supported by the Macula Foundation, Inc., New York, New York.

Reprint requests: Lawrence A. Yannuzzi, MD, LuEsther T. Mertz Retinal Research Center of Manhattan Eye, Ear and Throat Hospital, 210 East 64th Street, New York, NY 10021.

© 2005 by Ophthalmic Communications Society, Inc.