Original Article: PDF OnlyFREQUENCY OF PHOTOGRAPHICALLY APPARENT OPTIC DISC AND PARAPAPILLARY NERVE FIBER LAYER DRUSEN IN USHER SYNDROMEEDWARDS, AL MD, PhD; GROVER, SANDEEP MD; FISHMAN, GERALD A. MDAuthor Information From the Department of Ophthalmology and Visual Sciences, University of Illinois at Chicago, Chicago, Illinois Retina: Volume 16 - Issue 5 - p 388-392 Buy Abstract Purpose and Design: Using a retrospective case series, the authors determine the frequency and clinical features of optic disc and parapapillary nerve fiber layer drusen in type I and type II Usher syndrome (congenital deafness and retinitis pigmentosa). Methods: Color fundus photographs available on 43 patients with type I and 108 patients with type II Usher syndrome were analyzed for the presence of optic disc or parapapillary nerve fiber layer drusen. Results: Optic disc and/or parapapillary nerve fiber layer drusen were observed in 15 (35%) of 43 patients with type I Usher syndrome and 9 (8%) of 108 patients with type II Usher syndrome for whom color photographs were available. Bilateral drusen were observed in 11 patients (73%) with type I and 3 patients (33%) with type II Usher syndrome. In 3 (20%) of the 15 patients with type I and in 5 (56%) of the 9 patients with type II, only an isolated druse was seen. Six of the 15 patients with type I Usher syndrome showed parapapillary nerve fiber layer drusen, whereas the drusen were within the optic disc in all 9 patients with type II. Conclusions: Drusen of the optic disc and parapapillary nerve fiber layer tended to occur more frequently in type I than type II Usher patients and also were more often bilateral and multiple, with a tendency to occur in the parapapillary region and within the optic disc. © The Ophthalmic Communications Society, Inc.