Drugs of Abuse and Brain Gene Expression : Psychosomatic Medicine

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Special Issue: Psychopharmacology and Psychosomatic Research

Drugs of Abuse and Brain Gene Expression

Torres, German PhD; Horowitz, Judith M. PhD

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Psychosomatic Medicine 61(5):p 630-650, September 1999.


Addictive drugs like cocaine, ethanol, and morphine activate signal transduction pathways that regulate brain gene expression. Such regulation is modulated by the presence of certain transcription factor proteins present in a given neuron. This article summarizes the effects of several addictive drugs on transcriptional processes contributing to the development of a drug-dependent state. The characterization of drug-induced changes in gene expression shows promise for improving our understanding of drug-addiction phenomena and cellular modes of cocaine, ethanol, and morphine action.

Copyright © 1999 by American Psychosomatic Society

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