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SYSTEMATIC REVIEW/META-ANALYSIS

A Systematic Review of Somatic Symptoms in Children With a Chronically Ill Family Member

Elliott, Lindsey PhD; Thompson, Kathryn A. MA; Fobian, Aaron D. PhD

Author Information
doi: 10.1097/PSY.0000000000000799

Abstract

INTRODUCTION

Physical symptoms are not always adequately explained by a medical or organic condition, and several labels have been used to refer to these symptoms, including somatization, persistent somatic symptoms, and functional somatic symptoms (1). They are thought to be due to a combination of biological, psychological, interpersonal, and health care factors, and commonly present as pain, headaches, fatigue, chest pain, stomachaches, dizziness, or insomnia. The estimated prevalence of somatic symptoms in children and adolescents is between 10% and 30% (2,3).

Somatic symptoms can significantly impair patients’ lives. Adults with somatic symptoms report greater distress, decreased quality of life, and increased social isolation compared with patients who receive a medical diagnosis (4). In children, somatic symptoms have been associated with emotional and behavioral problems, school absences, and social impairments (5–7). Furthermore, individuals with somatic symptoms are high utilizers of the health care system and account for a substantial amount of health care costs (8).

In adults, somatic symptoms have been associated with exposure to familial illness (9). Furthermore, some literature has shown evidence of somatic symptoms in children and adolescents who have family members with cancer. Specifically, studies have found increased reports of sleep difficulties, headaches, stomachaches, dizziness, and loss of appetite (10–14). In addition, a review on the psychosocial impact of cancer on siblings identified a handful of studies that examined either somatic symptoms or physical quality of life. Evidence from this review was mixed, with some studies finding no difference in somatic symptoms in siblings compared with controls, and others finding differences based on sibling age and time since diagnosis. Older children and children whose ill sibling had been diagnosed less recently were more likely than controls to report somatic symptoms (15).

Social learning theory provides a potential model for the development of somatic symptoms in children and adolescents. Social learning theory suggests that somatic symptoms in children may be influenced by family members with a chronic illness in two ways. First, children may learn to display and manage somatic symptoms through a family members’ modeling of the symptoms. Second, family members may reinforce somatic symptoms displayed by children by giving them positive attention or allowing them to miss an undesirable activity (e.g., school) when they experience somatic symptoms (16,17). Research has demonstrated that somatic symptoms are more common in families in which somatic complaints are attended to by family members (18–21), and reinforced or modeled illness behaviors experienced in childhood are associated with higher rates of somatic symptoms in adulthood (22,23). Based on social learning theory, children may exhibit somatic symptoms in response to any chronic illnesses from which a family member models physical symptoms, especially if the symptom is reinforced in the child.

Based on existing evidence, well children of family members with a chronic illness may be particularly vulnerable to the development of somatic symptoms. However, the relationship between somatic symptoms and having a chronically ill family member is unclear. To our knowledge, there is no comprehensive systematic review of the literature that examines somatic symptoms in children and adolescents with a family member with any chronic illness. The aims of this article are to provide a systematic review of the existing literature on somatic symptoms in children and adolescents with either a parent or sibling with any chronic illness, evaluate the strength of the evidence based on the available research, and highlight future research directions.

METHODS

Systematic Review of the Literature

The following databases were searched for available articles before the search date of April 5, 2018: PubMed, EMBASE, PsychINFO, Scopus, CINAHL, and Cochrane. The review was registered with the PROSPERO registry (ID: CRD42018092344) and can be viewed at http://www.crd.york.ac.uk/PROSPERO.

Inclusion Criteria

  1. Humans
  2. English language articles
  3. Participants 17 years or younger, with a parent or sibling diagnosed with any chronic illness
  4. Studies measuring somatic symptoms or similar terms (e.g., medically unexplained symptoms)
  5. Studies comparing to a healthy control or normative data
  6. Published before April 5, 2018

Exclusion Criteria

Studies were excluded if they were not English language articles, participants were adults, or participants had a chronic illness. In addition, studies were excluded if the well-child was not compared with a healthy condition or normative data to ensure our review highlighted the unique risk for developing somatic symptoms in this population.

Study Search Terms

An initial general review of the literature identified articles that examined somatic symptoms in adolescents with an ill family member. From these articles, categories of search terms were identified as relevant for the study search strategy. Those categories included a) variations on terms for somatic symptoms, b) variations on chronic illnesses, and c) variations on family terminology. An example of the search syntax used in PubMed is provided in Supplemental Digital Content, http://links.lww.com/PSYMED/A617.

Study Selection

A PRISMA diagram (Figure 1) outlines the search and study selection process. Available articles were first screened by removing duplicates and any non-English language articles that were not screened out by applied filters in the original search. Articles were evaluated by all three authors by title and abstract to determine if each article met the inclusion/exclusion criteria before retrieving full articles. Full-text articles were then reviewed by the same three authors.

FIGURE 1
FIGURE 1:
PRISMA diagram and study search and selection process.

Risk of Bias Assessment

All included studies were evaluated for risk of bias. Two authors independently reviewed each article using the RTI Item Bank, which was developed specifically for identifying sources of bias and confounding in observational studies. Specifically the RTI Item Bank evaluates selection, performance, detection and attrition biases, confounding, selective outcome reporting, and overall quality of a study to determine the confidence of a reviewer that the observed effect in a study is the true effect (24). After an independent review, ratings were compared between the two authors; no significant discrepancies were found between raters.

RESULTS

Results of Literature Search

Twenty-seven unique studies were found that met all search criteria. Seventeen examined the relationship between somatic symptoms and having a parent with a chronic illness (12,25–41), and seven evaluated the relationship between somatic symptoms and having a sibling with chronic illness (42–48). In addition, we identified three studies that examined somatic symptoms in children with an ill relative but did not specify which relative was ill (49–51).

During the course of this review, three review articles that examined general psychosocial outcomes in adolescents with an ill family member were found. Although these reviews did not comprehensively evaluate somatic symptoms in this population, three articles from these reviews were identified as meeting the inclusion criteria and have been included in this systematic review.

Results of Parent Chronic Illness

Seventeen studies examined the relationship between somatic symptoms and having a parent with a chronic illness (Table 1). Thirteen studies found a significant positive association between having a parent with chronic illness and somatic symptoms (25–27,29,30,32,33,37–41,52). Of those 13 studies, 2 examined somatic symptoms in children of parents with AIDS. Asanbe et al. (25) found that South African children orphaned because of AIDS were at higher risk for somatic problems when compared with healthy controls who had not been orphaned. Similarly, Cluver and Gardner (29) reported that South African orphans because of AIDS were more likely to report stomachaches, headaches, or illness than controls matched for neighborhood, ethnicity, age, and sex. One study examined somatic symptoms in Australian children of parents with multiple sclerosis (MS) and found that 8- to 12-year-olds whose parents had MS reported more somatic symptoms than controls with healthy parents matched for sex, age, siblings, family structure, youth employment, residence, and socioeconomic status (33). Three studies that examined somatic symptoms in children with a parent with irritable bowel syndrome (IBS) were identified. Levy and colleagues (38) examined children of parents with IBS in two different studies. The first study found that children whose parents had IBS were more likely to make ambulatory clinic visits compared with controls with healthy parents, and those visits were more likely to be for gastrointestinal symptoms. Their second study found that children of parents with IBS report more bothersome gastrointestinal symptoms than controls with parents who were not diagnosed with a gastrointestinal condition. Similarly, van Tilburg et al. (39) found that children of parents with IBS report more nongastrointestinal and gastrointestinal symptoms than healthy controls. In addition, seven studies examined the relationship between somatic symptoms in children and the general health of their parents but did not specify which illness the parent had. Berntsson et al. (26,27) examined psychosomatic complaints in Swedish children and found that mother’s health status predicted somatic complaints in their children. Hotopf and colleagues (30) reported a strong positive association between persistent abdominal pain in children from the United Kingdom and their parents’ ratings of their health. Similarly, a study examined differences between Swedish children with and without recurrent abdominal pain (RAP) and found that children with RAP were more likely to have parents with poor self-reported health (32). Walker and colleagues (40) found that children with RAP were more likely to have relatives with abdominal disorders and more likely to live with a relative who had a serious health problem. Another study examined differences in Canadian adolescents referred to an outpatient psychiatry clinic with and without a parent with a physical illness; Morgan et al. (52) found that children who had parents with a self-reported illness of greater than 6 months reported more somatic symptoms compared with children whose parents were healthy. In a study examining the relationship between maternal health problems and child behaviors, Stein and Newcomb (37) found that maternal physical symptoms and subjective health significantly predicted somatic symptoms in their children.

TABLE 1
TABLE 1:
Parental Chronic Illness and Somatic Symptoms

Four studies found no association between having a parent with a chronic illness and somatic symptoms in the child. Two studies examined the relationship between somatic symptoms in children of parents with HIV/AIDS. Bursch et al. (28) found that at baseline somatic symptoms were similar in children of parents with HIV/AIDS and a standardized sample. Likewise, Ramos (35) found no significant difference in self-reported somatic symptoms in children of parents with AIDS and those with healthy parents. One study examined the relationship in Norwegian teenagers of parents with cancer, and found no difference in somatic symptoms in these teenagers compared with controls matched for sex, age, and municipality (31). Lastly, Petanidou and colleagues (34) examined family characteristics and their relationship with somatic symptoms in Greek adolescents, and found that parental self-report of health was not associated with somatic symptoms in the adolescents.

Results of Sibling Chronic Illness

Seven studies examined the relationship between having a sibling with a chronic illness and somatic symptoms (Table 2) (42–48). Four studies found a significant positive association between having a sibling with chronic illness and somatic symptoms (42,44,46,47), three of which examined somatic symptoms in siblings of children with cancer. In a study of healthy Israeli Jewish children with a sibling with cancer, Hamama et al. (44) reported significantly higher average somatic symptom scores in healthy siblings than scores of normative samples. Furthermore, they reported that somatic symptoms in siblings were positively associated with role overload, or the difference between the demands placed on an individual and the resources they have to meet those demands. Somatic symptoms in siblings were also negatively associated with self-control and self-efficacy. Massie (46) found that siblings of children with cancer reported higher somatic symptoms on the Child Behavior Checklist (CBCL) than normative data. In a study examining sibling adaptation to a childhood cancer diagnosis, Zeltzer and colleagues (47) found that siblings had higher somatic symptoms than did nonclinical normative samples, but lower than clinical samples according to both parent and self-report measures. Adolescent boys represented an exception and reported somatic symptoms scores as high as clinical samples.

TABLE 2
TABLE 2:
Sibling Chronic Illness and Somatic Symptoms

One study included siblings of children with various illnesses and disabilities (e.g., blindness, asthma, epilepsy, cancer, etc.), and found that siblings of children with chronic health problems were at a small risk for somatic symptoms (42).

Three studies found either no significant association or an inverse relationship between having a sibling with chronic illness and somatic symptoms when compared with control groups. Two of these studies examined siblings of children with cancer. Lahteenmaki et al. (45) examined outcomes of Finnish children with a sibling diagnosed with cancer, and found no difference between siblings and a control group on somatic symptoms. Similarly, Van Dongen-Melman and colleagues (48) found no difference between Dutch siblings of children who had successfully completed treatment of cancer and controls on somatic symptoms as measured by the CBCL. In addition, they demonstrated that siblings reported significantly less somatic symptoms than did controls on the Amsterdam Biographic Questionnaire for Children. Gold (43) examined adjustment in siblings of children diagnosed with sickle cell, and showed that siblings did not report clinically significant levels of somatic symptoms compared with sex matched normative data on the CBCL.

Results of Unspecified Relatives

Three studies examined the relationship between having an ill relative and somatic symptoms, without identifying which relative was ill (Table 3) (49–51). Domenech-Llaberia et al. (50) reported that children who frequently complained of somatic symptoms were more likely to have relatives with a chronic illness, most commonly asthma, than those who did not complain frequently. Poikolainen and colleagues (49) reported that a serious illness or injury in a family member predicted somatic symptoms in female members. Finally, Moffat and Redmond (51) found that a larger percentage of youth reported somatic symptoms when there were family health concerns present than when no concerns were present. However, youth somatic symptoms were lower when the family health concerns were disability and chronic illness than when they were depression, mental illness, or alcohol and drug use.

TABLE 3
TABLE 3:
Relative Not Specified

Results of Risk of Bias

Two studies merited high risk of bias (26,27), and 25 merited moderate risk of bias. This was primarily due to the nature of the design of the studies. Most studies were cross-sectional in nature, limiting the conclusions that can be drawn from the results of these studies. The exclusion criteria of the current review (i.e., requiring a healthy comparison group) may have eliminated several studies with high risk of bias.

DISCUSSION

Although research is limited, there seems to be evidence of increased somatic symptoms in children with a family member with a chronic illness, with the strongest evidence favoring a relationship between a parent with a chronic illness and childhood somatic symptoms. The majority of existing literature examining an ill parent and somatic symptoms in children reported an association between having an ill parent and somatic symptoms, with 13 of 17 studies reporting a significant relationship.

These findings are consistent with other research supporting the role of social learning theory in the development of somatic symptoms in children with an ill parent. Although genetics can contribute to the transmission of symptoms, one study compared the contribution of heredity versus social learning. In a study of 11,986 monozygotic and dizygotic twins, Levy and colleagues (53) found heredity and social learning to have an equal contribution in the development of IBS in children with parents diagnosed with IBS. In addition, several of the reviewed studies found that the somatic symptoms displayed in children were similar to the symptoms experienced by the ill parent. For example, Levy and colleagues (38,41) found that children of parents with IBS were more likely to exhibit gastrointestinal symptoms, and Walker and colleagues (40) demonstrated an increase in RAP in children with a parent with an abdominal disorder. This suggests that children may be more likely to experience symptoms that are directly modeled by parents. Furthermore, parents may be more likely to attend to and reinforce physical symptoms similar to those that they have experienced in their own chronic illness.

The evidence regarding the relationship between having a sibling with a chronic illness and somatic symptoms was somewhat mixed. Four studies reported a significant relationship between having an ill sibling and somatic symptoms (42,44,46,47), and three studies reported no relationship or an inverse relationship (43,45,48). Most studies examining the relationship between having an ill sibling and somatic symptoms were conducted in siblings of children with cancer (44–48), limiting the generalizability of the results to other disorders. Of the studies examining children with a sibling diagnosed with cancer, a significant relationship between having an ill sibling and somatic symptoms was found in studies comparing outcomes to normative data but not when compared with a matched healthy control population. This may contribute to the mixed literature on this relationship.

The difference in somatic symptoms in children with an ill parent versus an ill sibling is notable. Although any familial illness could potentially result in learned illness behavior, parent modeling of symptoms may be more salient to child and adolescent learning than modeling by other family members. Previous literature has suggested that adults are stronger models for learning than their peers or siblings (54). This could be due to the fact that the parent has more control over rewards and consequences related to illness behaviors (e.g., parent may allow or disallow a child to miss school). One study suggests that this relationship may also be stronger when the children are of the same sex as the ill parent. In a study examining somatic symptoms in Turkish adolescents with parents diagnosed with cancer, they reported greater somatic symptoms in boys than girls when the ill parent was the father compared with the mother (55). In addition, research on social learning theory suggests several factors that may influence learned behavior. In particular, older siblings and siblings of the same sex are more likely to serve as models than other sibling dyads (56). These differences in social learning from siblings may explain, at least in part, the mixed nature of the sibling literature found in this review.

Finally, three studies examined somatic symptoms in children without specifying which relative was ill. All three studies found evidence for a relationship between having an ill relative and somatic symptoms (49–51). This effect was found across each of the studies despite the variations in age range and method of symptom measurement.

There are several clinical implications from this review. These findings suggest that having an ill family member is related to somatic symptoms in children, with the strongest evidence for ill parents. Therefore, children with ill family members would benefit from prevention and early intervention methods to minimize the effects associated with having an ill family member. Medical professionals can educate parents with a chronic illness about the potential effects of the illness on their children. Parents can be encouraged to monitor their children for increased somatic symptoms and instructed how to avoid reinforcement of somatic symptoms. Early intervention may decrease distress for the child and family and have larger implications on the health care system, as somatic symptoms have been associated with greater medical care utilization and increased medical costs (57). In addition, programs can be developed for children with a family member with a chronic illness, which provide coping skills and support to prevent the development of somatic symptoms. Interventions for somatic symptoms can specifically address parental reinforcement of symptoms and symptom modeling in children with a family member with a chronic illness. Finally, as future research further elucidates this relationship, the understanding of additional mediators and moderators may allow for specific interventions that target the most at-risk families and strengthen potential protective factors.

Future Research Directions

A significant outcome of this review is the delineation of many areas that necessitate future research to further the understanding of somatic symptoms in children with a chronically ill family member. First, we suggest future studies examine somatic symptoms as a primary outcome. Second, research should assess all chronic illnesses as etiological factors for the development of somatic symptoms rather than focusing on individual illnesses. Somatic symptoms may be developed from any physical symptoms modeled by family members, and including all chronic illnesses will allow for the assessment of the overall effect of familial chronic illness on somatic symptoms in children. Furthermore, research can prospectively measure the impact of familial chronic illness by beginning to assess somatic symptoms in children and siblings of those with a chronic illness at the time of their diagnosis. This would allow for a stronger evidence-based etiological model of somatic symptoms as a learned illness behavior.

There are also several parental factors that may mediate or moderate the relationship between somatic symptoms in children and parent or sibling illness that need additional investigation. First, parenting style may impact whether somatic symptoms are learned by a child. One study found that across several cultures, higher parental warmth predicted lower somatic symptoms (58). Furthermore, parenting styles differ by culture, possibly leading to differing relationships between child somatic symptoms and parental illness among cultures. Comorbid parental mental health diagnoses may also significantly impact this relationship. There is evidence to suggest that depressed and/or anxious mothers display decreased parental warmth (59), which is associated with increased somatic symptoms (58,59). There is also evidence of both a genetic and a learned behavioral component to the transmission of anxiety and depression from parent to child, with children with anxious or depressed parents more likely to have the disorders themselves and engage in maladaptive thought patterns (59,60). Because anxiety and depression are related to increased somatic symptoms, these symptoms may be similarly transmitted to their children (61).

In addition to parental characteristics, sibling characteristics may play a role. Future studies should examine the effect of having an older versus a younger sibling with a chronic illness on somatic symptoms in children, as modeling of symptoms by older siblings may be more salient than in younger siblings. As previously mentioned, research has shown that adults have a larger effect on learned behaviors than peers or siblings, possibly due to increased control of rewards and consequences of behaviors (54). It is possible that older siblings also have some control over access to rewards and consequences for behaviors, though not to the same extent as parents.

Characteristics of the well-child may also affect learning of somatic symptoms, and future research should address if all children in the household are affected similarly by the presence of an ill family member. There is evidence that female individuals are more susceptible to learning behaviors compared with their male peers (40,62). Other child characteristics that may be important to examine could include comorbid anxiety or depression and child temperament (e.g., assertive children may be less likely to internalize modeled behaviors).

Finally, symptoms of the ill parent or sibling may also have an impact. Chronic illnesses that have been found to be transmitted through both genetic factors and social learning, such as IBS (53), may result in more somatic symptoms than those that are not transmitted through social learning (e.g., cancer). In addition, there is evidence in the IBS literature that children of parents with IBS display similar symptoms in the absence of an IBS diagnosis (38,41). This could suggest that children are more likely to display the symptoms directly modeled by the ill family member, and symptoms that are more overt (e.g., vomiting) may be more salient than symptoms that are less visible (e.g., dizziness). In addition, duration of illness may impact the relationship between having an ill family member and somatic symptoms. Previous research in learning theory and depression suggests that duration of time spent with a depressed parent was related to child outcomes (63,64). This suggests that increased exposure to parental behavior may result in longer periods of modeling and reinforcement with other behavioral outcomes, such as somatic symptoms, in the child. Learning may also be more salient when there is more significant impairment in the ill family member. Therefore, chronic illnesses that impact daily life more significantly or for longer periods (e.g., cystic fibrosis) may result in more significant somatic symptoms. This may increase the child’s exposure to these symptoms as well as provide models of potential secondary gain of symptoms. Similarly, somatic symptoms may differ between children whose parent died of a chronic illness and those who continue to live with a chronically ill parent. Future research should assess the severity of chronic illness in the family member on the development of somatic symptoms in children.

This review has several strengths. First, we provided a comprehensive systematic review of the existing literature on having a relative with an illness and somatic symptoms in children and adolescents. To our knowledge, this is the first systematic review to do so. Second, although the majority of the literature focuses on a single family chronic illness as an etiological factor for somatic symptoms in children and adolescents, this review is unique in that it included any chronic illness that met the criteria. Finally, this study outlines the mixed nature of the current literature, especially for siblings of those with chronic illnesses, and it highlights the need for continued study of somatic symptoms in children who have a relative with a chronic illness.

The literature on somatic symptoms in children with an ill family member is somewhat limited and has several weaknesses. First, there were several studies that relied on self-report ratings of health rather than specific diagnoses, at least in the parent illness literature (26,27,32,34,37,52). Furthermore, many studies focused on a single chronic illness, such as cancer or AIDS, limiting the generalizability of those studies. Also, a variety of measures were used to assess somatic symptoms in children and adolescents, ranging from self-reported symptoms to validated measures with somatization subscales. Similarly, only a handful of the studies (40,49,50) explicitly excluded children diagnosed with other health conditions, which could confound the findings of this review as somatic symptoms may instead be due to organic physical conditions in some of the participants. This is likely due to somatic symptoms not being the primary outcome measured by these studies, but rather a secondary finding. Despite this, many of the studies that did not control for other health conditions used measures of somatic symptoms that have scores comparable to normative data for somatic symptoms. An overwhelming majority of studies were cross-sectional and did not examine the longitudinal effects of having a parent or sibling with a chronic illness. In part due to study design, the literature included in this review all exhibited moderate to high risk of bias, suggesting a need for more rigorous study in this area. In addition, the sibling literature primarily focused on children diagnosed with cancer limiting the generalizability. Of note, many of the studies included in this review were not directly assessing somatic symptoms but included information on somatic symptoms as an indirect finding or in relation to overall psychosocial functioning. There were also a limited number of studies identified. However, every effort was made to identify appropriate search terms, which included a) variations on terms for somatic symptoms, b) variations on chronic illnesses, and c) variations on family terminology. Given that the search terms resulted in 3278 articles, these authors do not believe that the search terms used were overly limiting. This review only included studies using a healthy control population to determine significant differences between our population and the general population.

CONCLUSIONS

This systematic review highlights the relationship between having a chronically ill family member and somatic symptoms in children, especially among children of a parent with a chronic illness, and the need for continued research on the relationship. Based on social learning theory, any familial illness diagnosis could result in modeling of illness behaviors or reinforcement of illness behaviors by family members. Results indicate the strongest support for a relationship between having an ill parent and somatic symptoms. However, further research including a wider range of chronic illnesses is needed. Similarly, the research regarding having an ill sibling could benefit from expanding disease populations beyond research in cancer. In addition, this review calls for further research that is longitudinal in nature, following the course of the disease from diagnosis to remission and survivorship. Implications of this review include targeted prevention and treatment of somatic symptoms in children with family members with a chronic illness.

We would like to thank Carolyn Holmes and Geeta Malik with the Lister Hill Library at the University of Alabama at Birmingham for their assistance in developing the search strategy for this review.

Source of Funding and Conflicts of Interest: The authors have no financial relationships relevant to this article to disclose. Dr. Fobian’s work on this project was supported by Award Number 1K23DK106570-01A1 from the National Institute of Diabetes and Digestive and Kidney Diseases. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institute of Diabetes and Digestive and Kidney Diseases or the National Institutes of Health. The authors have no conflicts of interests relevant to this article to disclose.

Contributors’ Statement: Dr. Elliott conceptualized systematic review, met with librarians to develop search strategy, participated in article review for each stage of systematic review, drafted the initial manuscript, and reviewed and revised the manuscript. Ms. Thompson participated in article review for each stage of systematic review and reviewed and revised the manuscript. Dr. Fobian assisted with conceptualization of the systematic review, participated in article review for each stage of systematic review, reviewed and revised the manuscript, and mentored this review. All authors approved the final manuscript as submitted and agree to be accountable for all aspects of the work.

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Keywords:

somatic symptoms; parental illness; child heath; CBCL = Child Behavior Checklist; IBS = irritable bowel syndrome; MS = multiple sclerosis; RAP = recurrent abdominal pain

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