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Another Step Toward Clarifying the Benefits and Burdens of Selective Serotonin Reuptake Inhibitors

Wulsin, Lawson R. MD

doi: 10.1097/PSY.0000000000000735
EDITORIAL COMMENT
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ABSTRACT Selective serotonin reuptake inhibitors (SSRIs) have substantial beneficial effects for the treatment of major depressive mood disorders and other conditions but can also result in unwanted clinical outcomes. One of the reported disadvantages of SSRIs, based on cross-sectional studies, is their adverse effects on glycemic control. However, in this issue of Psychosomatic Medicine, Tharmaraja et al. report a meta-analysis of 16 randomized controlled trials, demonstrating beneficial effects of SSRIs on changes in glycemia. In this editorial, the advantages of meta-analysis in biobehavioral medicine are highlighted as well as the importance of the study designs (observational studies versus randomized controlled trials) on which the meta-analyses are based. This article concludes with an outline for future research directions in the area of SSRIs and glycemic control.

From the University of Cincinnati (Wulsin), Cincinnati, Ohio.

Address correspondence to Lawson R. Wulsin, MD, 260 Stetson Ave, Ste 3200, Cincinnati, OH 45219. E-mail: Lawson.wulsin@uc.edu

Received for publication June 10, 2019.

Online date: July 23, 2019

Copyright © 2019 by American Psychosomatic Society
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