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Brain Electrical Activity Associated With Visual Attention and Reactive Motor Inhibition in Patients With Fibromyalgia

González-Villar, Alberto J., PhD; Arias, Manuel, MD, PhD; Carrillo-de-la-Peña, María Teresa, PhD

doi: 10.1097/PSY.0000000000000677
ORIGINAL ARTICLES
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Objective Fibromyalgia (FM) is a generalized chronic pain condition associated with multiple cognitive impairments, including altered inhibitory processes. Inhibition is a key component of human executive functions and shares neural substrate with pain processing, which may explain the inhibitory deficits in FM. Here, we investigated the integrity of brain inhibitory mechanisms in these patients.

Methods We recorded the electroencephalographic activity of 27 patients with FM and 27 healthy controls (HCs) (all women) while they performed a reactive motor inhibition task (the stop-signal paradigm). We analyzed task-induced modulations in electrophysiological markers related to inhibition (N2, P3, and midfrontal theta oscillations) and visual attention (posterior alpha oscillations).

Results The FM group performed the task correctly, with no differences relative to HCs at the behavioral level. We did not find any between-group differences in N2 amplitude (F(1,52) = 0.01, p = .93), P3 amplitude (F(1,52) = 3.46; p = .068), or theta power (F(1,52) = 0.05; p = .82). However, modulation of posterior alpha power after presentation of either the go or stop stimuli was lower in patients than in HCs (F(1,52) = 7.98; p = .007).

Conclusions N2, P3, theta power, and behavioral results indicate that the mechanisms of motor inhibition are sufficiently preserved to enable correct performance of the stop-signal task in patients with FM. Nevertheless, the lower modulation of alpha suggests greater difficulty in mobilizing and maintaining visual attentional resources, a result that may explain the cognitive dysfunction observed in FM.

From the Psychophysiology Lab (González-Villar, Carrillo-de-la-Peña), Faculty of Psychology, Universidade de Santiago de Compostela, Santiago, Spain; Psychological Neuroscience Lab (González-Villar), Research Center in Psychology, School of Psychology, Universidade do Minho, Braga, Portugal; Departamento de Neuroloxía (Arias), Complexo Hospitalario Universitario de Santiago, Santiago de Compostela, Spain.

Address correspondence to Alberto J. González-Villar, PhD, Universidade de Santiago de Compostela, Santiago de Compostela, Galicia SPAIN. E-mail: albertojac.gonzalez@gmail.com

Received for publication May 1, 2018; revision received October 7, 2018.

Copyright © 2019 by American Psychosomatic Society
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