To examine the association of glycemia
status with cognition
among 600 Hispanics aged 55 to 64 years from Northern Manhattan.
was ascertained by history or hemoglobin A1c. Normal glucose tolerance and prediabetes
were ascertained with hemoglobin A1c. Memory was assessed with the Selective Reminding Test. Executive abilities were assessed using the Color Trails 1 and 2 and verbal fluency test. The cross-sectional association of glycemia
status with cognitive performance was examined using linear regression.
Participants had a mean age of 59.2 (2.9) years, 76.7% were women, and more than 65% had prediabetes
. HbA1C (β
= −0.97, p
< .001) and diabetes
= −2.06, p
= .001) were related with lower Selective Reminding Test total recall after adjustment for demographics, education, and vascular risk factors. Prediabetes
was associated with worse performance in Color Trail 2 (β
= −6.45 p
= .022) after full adjustment.
are related to worse memory and executive abilities in late middle age
, whereas prediabetes
is related only to worse executive abilities. Longitudinal follow-up is needed to understand the order and progression of these deficits.