This study investigated whether situational and dispositional optimism
were protective against dimensions of distress and aspects of health-related quality of life
(HQoL) in patients with ovarian cancer undergoing chemotherapy. This study also evaluated whether optimism
predicted a decrease in cancer antigen (CA) 125 levels during treatment.
Ninety women with epithelial ovarian cancer were assessed at the start and end of chemotherapy. Optimism
, distress, and HQoL were measured by self-report; CA 125
levels were gathered from patients' medical charts.
Both measures of optimism
were inversely associated with baseline anxiety
, perceived stress
, and depression
. In addition, situational optimism
was positively associated with baseline social and physical well-being, and dispositional optimism
was positively associated with baseline social and functional well-being. However, neither measure of optimism
predicted domains of distress or HQoL at the follow-up assessment after controlling for baseline levels. Dispositional optimism
predicted CA 125
at the end of treatment after controlling for baseline levels. However, neither situational nor dispositional optimism
predicted CA 125
falling to normal levels (≤35 U/mL).
Consistent with prior research, optimism
was inversely associated with distress and positively associated with HQoL in patients with ovarian cancer undergoing chemotherapy. Higher levels of dispositional optimism
at the start of chemotherapy were associated with a greater decline in patients' CA 125
CA = cancer antigen; HQoL = health-related quality of life; NK = natural killer; VEGF = vascular endothelial growth factor; PSS = Perceived Stress Scale; CES-D = Center for Epidemiologic Studies Depression Scale; FACT-O = Functional Assessment of Cancer Therapy-Ovarian; LOT-R = Life Orientation Test-Revised; TSOS = Treatment-Specific Optimism Scale; SES = socioeconomic status; SWB = social well-being; PWB = physical well-being; FWB = functional well-being; Δ = change; SD = standard deviation; SE = standard error; JOURNAL/psme/04.02/00006842-200607000-00007/ENTITY_OV0398/v/2017-07-26T061602Z/r/image-png = sample mean.