Most previous longitudinal studies demonstrating relationships between psychosocial variables and human immunodeficiency virus (HIV) disease progression
utilized samples of gay men accrued before the era of highly active antiretroviral treatment (HAART), without including viral load (VL) as an indicator of disease progression
or assessing the impact of medication adherence
. This study sought to determine whether psychosocial variables would predict both CD4 and VL changes in a diverse sample assessed entirely during the era of HAART and accounting for adherence
This longitudinal study assessed a multiethnic HIV+ sample (n
= 177) of men and women in the midrange of illness (CD4 number between 150 and 500; no previous acquired immunodeficiency syndrome [AIDS]–defining symptom) every 6 months for 2 years. Hierarchical linear modeling was used to model change in CD4 and VL controlling for sociodemographics (age, gender, ethnicity, education) and medical variables (baseline CD4/VL, antiretroviral medications at each time point, adherence
, hopelessness, and education predicted the slope of CD4 and VL. Avoidant coping
and life event stress
predicted VL change. Cumulative variables produced stronger relationships (depression
, avoidant coping
, and hopelessness with CD4/VL slope and life events stress
with VL slope). High cumulative depression
and avoidant coping
were associated with approximately twice the rate of decline in CD4 as low scorers and greater relative increases in VL. Social support was not significantly related to CD4 or VL slope.
Psychosocial factors contribute significantly to the variance in HIV disease progression
(assessed through CD4 number and VL) in a diverse sample, accounting for adherence
and do so in the era of HAART.
HAART = highly active antiretroviral treatment; VL = viral load; HIV = human immunodeficiency virus; AIDS = acquired immunodeficiency syndrome; PI = protease inhibitor; HLM = hierarchical linear modeling; DR = decline ratio; SES = socioeconomic status; BDI = Beck Depression Inventory; BHS = Beck Hopelessness Scale; N/A = not applicable.