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Effect of Comorbid Chronic Diseases on Prevalence and Odds of Depression in Adults With Diabetes

Egede, Leonard E. MD, MS

doi: 10.1097/01.psy.0000149260.82006.fb
Original Articles

Objective: The objective of this study was to determine the effect of coexisting chronic conditions on prevalence and odds of depression in individuals with diabetes.

Methods: Data on 1794 adults with diabetes from the 1999 National Health Interview Survey were analyzed. Six chronic conditions were identified: hypertension, coronary artery disease, chronic arthritis, stroke, chronic obstructive pulmonary disease, and end-stage renal disease. Chronic conditions were counted and categorized into 4 groups: diabetes alone, diabetes + 1 condition, diabetes + 2 conditions, and diabetes + 3 or more conditions. Prevalence of depression was calculated by number of chronic conditions and for each condition. Adjusted odds of depression were calculated by number of chronic conditions and for each chronic condition while simultaneously controlling for covariates and for each chronic condition using multiple logistic regression. STATA was used for statistical analyses.

Results: Using diabetes alone as reference, adjusted odds of major depression by number of conditions were: diabetes + 1 (1.31; 95% confidence interval [CI], 0.67–2.55), diabetes + 2 (2.09; 95% CI, 1.06–4.12), and diabetes + 3 or more (4.09; 95% CI, 2.04–8.17). Adjusted odds of major depression for each coexisting chronic conditions were: hypertension (1.22; 95% CI, 0.78–1.90), coronary artery disease (2.00; 95% CI, 1.27–3.14), chronic arthritis (2.02; 95% CI, 1.35–3.02), stroke (2.15; 95% CI, 1.10–4.31), chronic obstructive pulmonary disease (0.96; 95% CI, 0.52–1.81), and end-stage renal disease (1.19; 95% CI, 0.57–2.49).

Conclusion: Odds of major depression are significantly increased among adults with diabetes in the presence of two or more coexisting chronic conditions, and coexistence of coronary artery disease, chronic arthritis, and stroke in particular, are associated with increased odds of major depression.

CAD= coronary artery disease

COPD = chronic obstructive pulmonary disease

ESRD = end-stage renal disease

NHIS = National Health Interview Survey

CIDI-SF = Composite International Diagnostic Survey Short Form

DSM-IV = Diagnostic and Statistical Manual of Mental Disorders, 4th Edition.

From the Department of Medicine & Center for Health Care Research, Medical University of South Carolina, Charleston, South Carolina and Ralph H. Johnson VA Medical Center, Charleston, South Carolina.

Address correspondence and reprint requests to Leonard E. Egede, MD, Medical University of South Carolina, Center for Health Care Research, 135 Cannon Street, Suite 403, P.O. Box 250837, Charleston, SC 29425. E-mail:

Received for publication April 27, 2004; revision received July 22, 2004.

Dr. Egede is supported by grant #5K08HS11418 from the Agency for Health Care Research and Quality, Rockville, Maryland. Dr. Egede is a Staff Physician at the Ralph H. Johnson VAMC, Charleston, SC. The contents of this publication are solely the responsibility of the author and do not necessarily represent the official views of the Agency for Health Care Research and Quality or the Centers for Disease Control and Prevention.

Copyright © 2005 by American Psychosomatic Society
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