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Daily Psychosocial Stressors Interfere With the Dynamics of Urine Neopterin in a Patient With Systemic Lupus Erythematosus: An Integrative Single-Case Study

Schubert, Christian MD; Lampe, Astrid MD; Rumpold, Gerhard MS; Fuchs, Dietmar PhD; König, Paul MD; Chamson, Emil BA; Schüssler, Gerhard MD


Objective Systemic lupus erythematosus (SLE) is a chronic autoimmune disease characterized by flare-ups, the causes of which are not known. In accordance with new concepts in stress research, this study investigated whether daily psychosocial stressors interfere with immunological processes in SLE. Because such processes are unique to each individual, single-case design using time-series analysis (Box and Jenkins) was applied.

Methods A 40-year-old woman with SLE (last flare-up September 1995) was interviewed initially to determine major life events and difficulties (using the Life Events and Difficulties Schedule) in the previous 2 years. She was then observed for 63 days. Urine neopterin, an immunological parameter demonstrated to parallel disease activity in SLE patients, was measured in daily overnight urine. Daily incidents were identified weekly by the Incidents and Hassles Inventory and independently rated. Intervening factors, including infections, medication, and lifestyle, were controlled.

Results Retrospectively, data obtained from the Life Events and Difficulties Schedule indicated that major life events and difficulties had preceded the patient’s last flare-up in 1995. Although there were no clinical signs of SLE during this prospective study of 63 days, cross-correlational analyses revealed that “moderately” stressful incidents associated with higher levels of emotional irritation (lag 0: +0.271, p< .05) predicted an increase in urine neopterin the following day (lag 1: +0.441, p< .05). Moreover, a 7-day cyclicity in neopterin levels that corresponded to the weekly examinations and interviews was found.

Conclusions This study showed a causal relationship between psychosocial stressors and urine neopterin concentrations that may be related to SLE disease activity. Furthermore, the workability of an integrative approach using single-case design and time-series analysis in psychoneuroimmunology was demonstrated for the first time.

From the Departments of Medical Psychology and Psychotherapy (C.S., A.L., G.R., E.C., G.S.) and Internal Medicine (P.K.), University Hospital Innsbruck, and Institute of Medical Chemistry and Biochemistry (D.F.), University Innsbruck, Innsbruck, Austria.

Received for publication July 21, 1998;

revision received May 13, 1999.

Address reprint requests to: Christian Schubert, MD, Department of Medical Psychology and Psychotherapy, University Hospital Innsbruck, Sonnenburgstrasse 9, A-6020 Innsbruck, Austria. Email:

Copyright © 1999 by American Psychosomatic Society
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