Welcome to the January/February 2023 issue of the Journal of Clinical Psychopharmacology (JCP). There are many thought-provoking and informative papers in this issue. I would like to highlight a few of them. On pages 1-2, Dr. Richard Shader, Founding Editor-in-Chief, Emeritus of JCP, has written a Guest Editorial titled, “Statistical Versus Clinical Significance: A Question About Caplyta (Lumateperone)". In the Editorial, Dr. Shader contrasts the differences in the pictures painted by direct-to-consumer advertising on television with the data from a single published report of lumateperone for the treatment of episodes of depression in bipolar disorder.
The approval of medications for the treatment of psychiatric illness varies from country to country. In a Commentary on pages 3-5, Drs. Rishab Gupta and Swarndeep Singh critique the Indian government's decision to approve endoxifen for the treatment of acute mania in adults.
The commentary has an accompanying podcast.
On pages 6-11, Dr. Rakesh Kumar and colleagues, in a paper titled, “Real-World Clinical Practice Among Patients With Bipolar Disorder and Chronic Kidney Disease on Long-term Lithium Therapy," used a 2-year mirror-image study design to investigate changes in clinical characteristics, pharmacotherapeutic treatments for medical/psychiatric disorders, and outcomes among patients with bipolar disorder and chronic kidney disease on long-term lithium therapy.
There is an accompanying podcast with Dr. Kumar and senior author Dr. Balwinder Singh.
Finally, on pages 12-19, Dr. Kim Dao and colleagues, in a paper titled, “Reproductive Safety of Trazodone After Maternal Exposure in Early Pregnancy: A Comparative ENTIS Cohort Study," present data from a multicenter, observational prospective cohort study which compared pregnancy outcomes in women exposed to trazodone in early pregnancy against those in a reference group of women exposed to a selective serotonin reuptake inhibitors.
And as you will see, there are many other interesting Original Contributions, Brief Reports, and Letters to the Editor in the January/February 2023 issue!
Anthony J. Rothschild, MD
