Original ContributionsThe Impact of Antipsychotics on Psychomotor Performance With Regards to Car Driving SkillsBrunnauer, Alexander PhD*; Laux, Gerd MD*†; Geiger, Elisabeth MS*; Möller, Hans-Jürgen MD†Author Information *Psychiatric Clinic, District Hospital Gabersee, Wassenberg/Inn, Germany; †Department of Psychiatry, University of Munich, Munich, Germany. Received July 31, 2002; accepted after revision September 26, 2003. Address correspondence and reprint requests to Alexander Brunnauer, PhD, Department of Neuropsychology, Bezirksklinikum Gabersee, D-83512 Wasenburg/Inn, Germany. E-mail: [email protected]. Journal of Clinical Psychopharmacology: April 2004 - Volume 24 - Issue 2 - p 155-160 doi: 10.1097/01.jcp.0000116648.91923.82 Buy Metrics Abstract Cognitive and psychomotor impairments are a core feature of most patients with schizophrenia and may have an important influence on driving ability. The present study investigated the effects of neuroleptic monotherapy on psychomotor functions related to car driving skills in schizophrenic patients. Consecutively admitted schizophrenic inpatients (n = 120) were tested under steady state plasma level conditions before discharge to outpatient treatment. Patients met the International Classification of Diseases, Tenth Revision criteria for schizophrenia. The study followed a naturalistic nonrandomized design. Data were collected with the computerized Act & React Testsystem and were analyzed according to medication, severity of illness, and age. Only 32.5% of the schizophrenic inpatients passed the tests without major impairments. Patients treated with atypical neuroleptics or clozapine showed a better test performance on skills related to driving ability when compared with patients on typical neuroleptics. Differences were most pronounced in measures of divided attention, stress tolerance, and attention. Data also suggest that treatment with clozapine had an overall positive impact on measures of reactivity and stress tolerance. These results show that even under steady state pharmacologic conditions psychomotor functions of most schizophrenic patients partly remitted must be considered as impaired. To evaluate these effects, a systematic neuropsychologic examination is recommended. © 2004 Lippincott Williams & Wilkins, Inc.