Articles: PDF OnlyAbuse Potential of Buspirone and Related DrugsBALSTER, ROBERT L. PhD Author Information Department of Pharmacology and Toxicology, Medical College of Virginia, Virginia Commonwealth University, Richmond, Virginia Address requests for reprints to Dr. Balster, Department of Pharmacology and Toxicology. Medical College of Virginia, Box 613—MCV Station, Richmond, VA 23298-0613. (J Clin Psychopharmacol 1990;10:31S-37S) Journal of Clinical Psychopharmacology: June 1990 - Volume 10 - Issue 3 - p 31S-37S Buy Abstract Scientific evidence regarding the drug abuse potential of buspirone and gepirone is reviewed. In animal studies, the pharmacologic profile of buspirone differs from that of other classes of abused drugs. Buspirone does not share discriminative stimulus effects with abused depressants, and it is not self-administered. New data are presented showing a lack of reinforcing effects for gepirone in rhesus monkeys when the drug was evaluated in an intravenous drug self-administration procedure. Studies of the acute effects of buspirone conducted in human subjects provide no evidence of abuse potential, and there is no indication that the drug has been abused to any extent since being marketed in December 1986. Available evidence suggests that the azapirones buspirone and gepirone have little, if any, potential for abuse. © Williams & Wilkins 1990. All Rights Reserved.