Secondary Logo

Journal Logo

Institutional members access full text with Ovid®

Optimal Dosing of Risperidone and Olanzapine in the Maintenance Treatment for Patients With Schizophrenia and Related Psychotic Disorders: A Retrospective Multicenter Study

Yoshimura, Yusaku MD*†; Takeda, Toshihiko MD, PhD; Kishi, Yoshiki MD, PhD; Harada, Toshiki MD, PhD§; Nomura, Akira MD, PhD; Washida, Kenji MD, PhD*†; Yoshimura, Bunta MD; Sato, Kojiro MD; Yada, Yuji MD; Aoki, Shozo MD, PhD*

Journal of Clinical Psychopharmacology: June 2017 - Volume 37 - Issue 3 - p 296–301
doi: 10.1097/JCP.0000000000000689
Original Contributions

Objectives This study aims to determine the optimal tolerability dose ranges of risperidone (RIS) and olanzapine (OLZ) administered during schizophrenia maintenance phase.

Methods Two-year continuation rates of prescription at discharge were examined using a retrospective cohort study method. Adult patients with schizophrenia and related psychotic disorders, receiving antipsychotic monotherapy with RIS or OLZ at discharge, were included. The primary outcome measures were the time to treatment discontinuation and 2-year continuation rates at 4 modal dose ranges of each drug. We estimated the optimal tolerability dose ranges by comparing the continuation rates at various modal doses.

Results Of 648 patients, 344 received RIS and 304 received OLZ. The RIS 2-year continuation rates at 4 daily modal dose ranges were significantly different (0.5–2.5 mg: 46.0%, 3.0–5.0 mg: 40.0%, 5.5–7.5 mg: 30.0%, and 8.0–10.0 mg: 28.0%), with the difference favoring RIS at lower doses (0.5–5.0 mg) more than higher doses (5.5–10.0 mg). In contrast, there were no significant differences among OLZ 4 modal dose ranges (2.5–7.5 mg: 49.1%, 10.0–15.0 mg: 42.6%, 17.5–22.5 mg: 40.9%, and 25.0–30.0 mg: 39.0%). The time to treatment discontinuation significantly favored OLZ over RIS. However, it did not significantly differ between RIS and OLZ at lower doses.

Conclusions It is suggested that the optimal tolerability dose range during maintenance treatment is 0.5 to 5.0 mg/d for RIS and 2.5 to 30 mg/d for OLZ, and that RIS at lower doses is comparable with OLZ at lower doses.

From the *Department of Psychiatry, Kawasaki Medical Graduate School, Kurashiki; †Zikei Hospital; ‡Okayama Psychiatric Medical Center, Okayama; §Taiyo Hills Hospital, Takahashi; and ∥Momonosato Hospital, Kasaoka, Japan.

Received July 12, 2016; accepted after revision January 24, 2017.

Reprints: Yusaku Yoshimura, MD, Department of Psychiatry, Kawasaki Medical Graduate School, 577, Matsushima, Kurashiki, Japan (e-mail:

This study was supported by a grant from the SENSHIN Medical Research Foundation. The funder had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.

Copyright © 2017 Wolters Kluwer Health, Inc. All rights reserved.