Secondary Logo

Journal Logo

Institutional members access full text with Ovid®

A New Nomenclature for Psychotropic Drugs

Ghaemi, S. Nassir MD, MPH

Journal of Clinical Psychopharmacology: August 2015 - Volume 35 - Issue 4 - p 428–433
doi: 10.1097/JCP.0000000000000341
Original Contributions

Introduction Current classifications of psychotropic drugs, developed in the 1960s, are based on beliefs about clinical effectiveness. This article evaluates the scientific validity of current drug terms and possible alternative classifications.

Methods A historical, conceptual, and empirical review of the psychopharmacology literature is provided. Consistency of classification is examined by 3 major categories: chemical structure, pharmacodynamic mechanism, and clinical efficacy.

Results Current drug terms based on clinical effectiveness are not valid scientifically, either claiming efficacy which is disproven or ignoring other areas of clinical efficacy. Hence, clinical efficacy is not a consistent and scientifically valid way of classifying psychotropic drugs. Chemical structures are also heterogeneous for drugs with similar clinical efficacy. The most consistent way to define drug classes is pharmacodynamic mechanism. Specific drug groups identified are: monoamine agonists (“antidepressants” and “stimulants”), dopamine blockers (“antipsychotics”), second messenger modifiers (“mood stabilizers), and gabaergic agonists (“anxiolytics” or “hypnotics”).

Conclusions Consistent with a recent proposal of psychopharmacology organizations, this article proposes a new nomenclature based mainly on biological pharmacodynamic mechanisms. Specific terms that are scientifically valid and clinically practical are suggested. It is hoped that this new language would allow for more meaningful and accurate communication between clinicians and patients.

From the Mood Disorders Program, Tufts Medical Center, Department of Psychiatry, Tufts University Medical School, Boston, MA.

Received May 19, 2014; accepted after revision March 23, 2015.

Reprints: S. Nassir Ghaemi, MD, MPH, Tufts Medical Center, 800 Washington St., Boston, MA 02111 (e-mail:

Copyright © 2015 Wolters Kluwer Health, Inc. All rights reserved.