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Rivastigmine as an Effective Add-On to Standard Treatment of Veterans With Chronic Posttraumatic Stress Disorder: A Case Series

Fayyazi Bordbar, Mohammad Reza MD; Talaei, Ali MD

Journal of Clinical Psychopharmacology: October 2013 - Volume 33 - Issue 5 - p 706–709
doi: 10.1097/JCP.0b013e31829a88ed
Brief Reports

Background After 23 years of the end of the Iran-Iraq war, the country is left with many patients with chronic posttraumatic stress disorder (PTSD) who need close psychiatric services and are in need for recurrent hospitalization. So far, there are no reports of the rivastigmine use in PTSD patients. We report dramatic reduction of symptoms in 3 veterans with chronic PTSD, after rivastigmine augmentation.

Case Presentation This report describes the efficacy of rivastigmine as an add-on to standard treatment of 3 Iranian male veterans with chronic PTSD (aged 52, 46, and 45 years) with severe active symptoms in all 3 dimensions of the disorder. Although they had gone through many approved drug treatments (selective serotonin reuptake inhibitors, tricyclic antidepressants, mood stabilizers, antipsychotics, benzodiazepines, β-blockers, and so on), from the beginning of the disorder, their recovery remained poor (PTSD Checklist–Military Version [PCL-M] scores were 67, 71, and 73 before rivastigmine add-on). Rivastigmine was added to the ongoing therapeutic regimens of the patients for 6 months.

Evaluating their condition with PCL-M after 1 and 6 months of treatment showed a significant improvement in patients with PTSD (PCL-M scores were 37, 40, and 47 and dropped to 30, 27, and 31, respectively). Hyperarousal symptoms of PTSD in patients are noted to be the most improved. The rivastigmine add-on experience did not report any adverse effects.

Conclusions The present study showed that rivastigmine is an effective and safe add-on to treatment of patients with chronic PTSD. This effect could be due to improved cognitive status or cholinergic-adrenergic balance adjustment in patients.

From the Psychiatry and Behavioral Sciences Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.

Received July 16, 2012; accepted after revision January 18, 2013.

Reprints: Ali Talaei, MD, Ibn-e-Sina Hospital, Hor-e-Ameli Blvd, Mashhad, Iran (e-mail:

© 2013 by Lippincott Williams & Wilkins.