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Dysregulation of Adipocytokines Related to Second-Generation Antipsychotics in Normal Fasting Glucose Patients With Schizophrenia

Sugai, Takuro MD, PhD; Suzuki, Yutaro MD, PhD; Fukui, Naoki MD, PhD; Ono, Shin MD; Watanabe, Junzo MD, PhD; Tsuneyama, Nobuto MD; Someya, Toshiyuki MD, PhD

Journal of Clinical Psychopharmacology: June 2012 - Volume 32 - Issue 3 - p 390–393
doi: 10.1097/JCP.0b013e3182524393
Brief Reports

Objective The underlying mechanism for second-generation antipsychotic (SGA)-related glucose-lipid metabolic dysfunction is not fully understood. Recent studies have suggested a possible impact of SGAs on endocrine regulation, especially on adipocytokines. We examined the effect of each SGA on various adipocytokines in normal fasting glucose (NFG) subjects.

Method The study population comprised 113 Japanese inpatients with schizophrenia who were treated with olanzapine, risperidone, or quetiapine, and 123 healthy control (CONT) volunteers. All of the subjects were diagnosed with NFG. Plasma concentration of adiponectin, leptin, tumor necrosis factor α, total cholesterol, triglyceride, high-density lipoprotein cholesterol, and low-density lipoprotein cholesterol were compared between the SGA and CONT groups.

Results Second-generation antipsychotic subjects had significantly higher leptin levels in comparison to the CONT subjects. The plasma concentration of adiponectin, total cholesterol, and high-density lipoprotein cholesterol in the SGA subjects were significantly lower than those in the CONT subjects. There were no significant differences in tumor necrosis factor α, triglyceride, and low-density lipoprotein cholesterol levels between the 2 groups. In a stepwise multiple regression analysis, olanzapine was found to be a factor that contributed to decreased adiponectin levels, and the CONT subjects were detected to be a factor associated with lower leptin levels.

Conclusions The present study indicates the possibility that the administration of SGAs may affect adipocytokines in the NFG stage, excluding the impaired fasting glucose group, which is in the transition stage into diabetes mellitus.

From the Department of Psychiatry, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan.

Received February 10, 2011; accepted after revision November 18, 2011.

Reprints: Toshiyuki Someya, MD, PhD, Department of Psychiatry Niigata University Graduate School of Medical and Dental Sciences, 757 Asahimachidori-ichibancho, Chuo-ku, Niigata 951-8510, Japan (e-mail:

This study was funded by a Grant-in-Aid for Scientific Research (KAKENHI) from the Japan Society for the Promotion of Science (JSPS; #22791112 and #21791117) to Dr Fukui and a Grant-in-Aid for Scientific Research (KAKENHI) from JSPS (#17591199 and #19591344) and Mitsubishi Pharma Research Foundation and Health and Labour Sciences Research grants (Research on Psychiatric and Neurological Diseases and Mental Health, H17-kokoro-002) to Dr Someya. All funding sources had no role in the study design; in the collection, analysis, and interpretation of the data; in the writing of the report; or in the decision to submit the paper for publication.

© 2012 Lippincott Williams & Wilkins, Inc.