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Different Impacts of Aquaporin 4 and MAOA Allele Variation Among Olanzapine, Risperidone, and Paliperidone in Schizophrenia

Chung, Ting-Sheng MD*; Lung, For-Wey MD, ScD†‡

Journal of Clinical Psychopharmacology: June 2012 - Volume 32 - Issue 3 - p 394–397
doi: 10.1097/JCP.0b013e31825370f4
Brief Reports

Apoptosis has been considered to be involved in schizophrenia. Water channels are modulated just before apoptosis. In the aquaporin family, aquaporin 4 (AQP-4) is most highly expressed in the brain and is supposed to play an important role in a neuronal environment. In this clinical study, we investigated the relationship between the AQP-4 polymorphism and drug response in schizophrenia under the control of the MAOA (monoamine oxidase A) promoter gene. We recruited 91 patients with schizophrenia, and they were randomized to receive olanzapine (n = 44), risperidone (n = 23), or paliperidone (n = 24). Genotyping of AQP-4 and MAOA polymorphisms was done in all patients. Patients with the AQP-4 non-C polymorphism needed a higher dosage of olanzapine for treatment (z = 4.163, P = 0.041), and patients with a short form of the MAOA polymorphism needed a higher dosage of risperidone for treatment (z = 5.124, P = 0.024). Patients who smoked cigarettes needed a higher dosage of olanzapine for treatment (z = 4.905, P = 0.027), but cigarette smoking did not affect the dosage of paliperidone. The AQP-4 polymorphism may have an effect in influencing the dosage of olanzapine. However, the roles of AQP-4 polymorphisms in the blood-brain barrier and different neuroprotective effects need further exploration in future studies.

From the *Department of Psychiatry, Kaohsiung Armed Forces General Hospital, Kaohsiung; †Songde Branch, Taipei City Hospital; and ‡Department of Psychiatry, National Defense Medical Center, Taipei, Taiwan.

Received April 4, 2011; accepted after revision November 18, 2011.

Reprints: For-Wey Lung, MD, ScD, Taipei City Psychiatric Center, Taipei City Hospital, No. 309, Songde Rd, Xinyi District, Taipei City 11080, Taiwan (e-mail:

© 2012 Lippincott Williams & Wilkins, Inc.