Original ContributionsGray Matter Deficits in Panic Disorder A Pilot Study of Meta-AnalysisLai, Chien-Han MDAuthor Information From the Department of Psychiatry, Buddhist Tzu-Chi General Hospital, Taipei Branch; and Institute of Brain Science, National Yang Ming University, Taipei, Taiwan. Received May 25, 2010; accepted after revision February 14, 2011. Reprints: Chien-Han Lai, MD, Buddhist Tzu-Chi General Hospital, Taipei Branch, 289 Jianguo Rd, Xindian City, Taipei County 231, Taiwan (e-mail: [email protected]). The author did not receive financial and material support. Journal of Clinical Psychopharmacology: June 2011 - Volume 31 - Issue 3 - p 287-293 doi: 10.1097/JCP.0b013e31821a1045 Buy Metrics Abstract Objective: This study aimed to conduct a meta-analysis of published voxel-based morphometry studies in panic disorder (PD). Methods: Six data sets consisting of patients with PD and healthy controls were enrolled for this meta-analysis. A new improved voxel-based meta-analytic tool, signed differential mapping, was used to explore deficits of gray matter volume in PD patients compared to the control group. Results: Patients with PD had decreased regional gray matter volumes in right caudate head (uncorrected P = 0.0002) and right parahippocampal gyrus (uncorrected P = 0.0005). These regions could be confirmed in the following jackknife sensitivity analysis. The meta-regression results showed that the included patients with more severe PD tended to have more deficits of gray matter volume in the right basal ganglion (uncorrected P = 0.0008). Conclusions: Patients with PD possibly have decreased gray matter volumes in the striatolimbic areas. However, more studies with whole-brain voxel-based morphometry in PD and first-episode drug-naive studies might elucidate structural deficits. © 2011 Lippincott Williams & Wilkins, Inc.