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Postpartum Depression: A Randomized Trial of Sertraline Versus Nortriptyline

Wisner, Katherine L. MD, MS*†; Hanusa, Barbara H. PhD; Perel, James M. PhD; Peindl, Kathleen S. PhD; Piontek, Catherine M. MD§; Sit, Dorothy K. Y. MD; Findling, Robert L. MD; Moses-Kolko, Eydie L. MD

Journal of Clinical Psychopharmacology: August 2006 - Volume 26 - Issue 4 - p 353-360
doi: 10.1097/
Original Contributions

Abstract: Symptom reduction and improvement in functioning in women with postpartum major depression treated with a tricyclic antidepressant versus a serotonin reuptake inhibitor were compared. The design was a double-blind, 8-week comparative trial of nortriptyline (NTP) versus sertraline (SERT) with a 16-week continuation phase. Women aged 18 to 45 years with postpartum major depression and a 17-item Hamilton Rating Scale for Depression score of 18 or more were eligible. Subjects were randomized to NTP or SERT and treated with a fixed-dosing strategy. Of 420 women interviewed, 109 eligible women received medication, and 95 provided follow-up data. The proportion of women who responded and remitted did not differ between drugs at 4, 8, or 24 weeks. Times to response and remission also did not differ. Psychosocial functioning improved similarly in both drug-treated groups of mothers. The total side effect burden of each drug was similar, although side effect profiles differed between agents. No clinical or demographic variables differentiated responders by drug. Women who were responders and remitters at week 8 could be identified earlier if they were treated with SERT than with NTP. Breast-fed infant serum levels were near or below the level of quantifiability for both agents.

*Department of Obstetrics and Gynecology and Reproductive Sciences, Epidemiology and Women's Studies; †Women's Behavioral Health CARE, Western Psychiatric Institute and Clinic/University of Pittsburgh Medical Center, Pittsburgh, PA; ‡Department of Psychiatry, Duke University Medical Center, Raleigh/Durham, NC; §Interlink Healthcare Communications, Lawrenceville, NJ and ∥Department of Psychiatry, Case Western Reserve University/University Hospitals Health System; Cleveland, OH.

Received November 15, 2005; accepted after revision May 4, 2006.

Address correspondence and reprint requests to Katherine L. Wisner, MD, MS, Obstetrics and Gynecology and Reproductive Sciences, Epidemiology, and Women's Studies, Women's Behavioral HealthCARE, Western Psychiatric Institute and Clinic/University of Pittsburgh Medical Center, 3811 O'Hara St, Pittsburgh, PA 15213. E-mail:

© 2006 Lippincott Williams & Wilkins, Inc.