ArticlesUse of Atypical Antipsychotic Agents in Bipolar and Schizoaffective Disorders Review of the Empirical LiteratureGhaemi, S. Nassir MD; Goodwin, Frederick K. MDAuthor Information (Ghaemi, Goodwin) Center on Neuroscience, Medical Progress, and Society, Department of Psychiatry, George Washington University, Washington, DC; (Ghaemi) Department of Psychiatry, Massachusetts General Hospital, Boston, Massachusetts Received December 18, 1997; accepted after revision July 21, 1998. Address requests for reprints to: S. Nassir Ghaemi, MD, Massachusetts General Hospital, Department of Psychiatry, WACC-812, 15 Parkman Street, Boston, MA 02114. Address e-mail to: [email protected] Journal of Clinical Psychopharmacology: August 1999 - Volume 19 - Issue 4 - p 354-361 Buy Abstract Atypical antipsychotic agents seem to be effective treatments for bipolar disorder, especially as adjunctive treatments.They may be a safer and more effective alternative to the common practice of maintenance adjunctive treatment with traditional antipsychotic agents in patients with bipolar disorder. However, currently available research studies are limited methodologically mainly to open-label, uncontrolled designs. Further research is required before the definitive efficacy of these agents in bipolar disorder is established. If randomized or double-blind data support the open-label data reviewed here, atypical antipsychotic agents may possess an important role in the adjunctive treatment of bipolar disorder. (J Clin Psychopharmacol 1999;19:354-361) © 1999 Lippincott Williams & Wilkins, Inc.