Original Article: PDF OnlyA Controlled Study of Trazodone, Imipramine, and Placebo in Outpatients with Endogenous DepressionMANN, J JOHN MD; GEORGOTAS, ANASTASE MD; NEWTON, ROGER MD*; GERSHON, SAMUEL MD†Author Information Department of Psychiatry, New York University Medical Center, New York, New York * Mead Johnson Pharmaceutical Division, Evansville, IN 47721 † Chairman and Professor at Wayne State University, Detroit, MI. Journal of Clinical Psychopharmacology: March 1981 - Volume 1 - Issue 2 - p 75-80 Buy Abstract A 4-wk double-blind controlled study of the antidepressant efficacy of the triazolopyridine derivative trazodone, in contrast to imipramine and placebo, was carried out in 30 endogenously depressed outpatients. Trazodone was found to be equivalent in efficacy to imipramine and statistically significantly superior to placebo. Trazodone showed a significant antidepressant effect relative to placebo when outcome was measured after only 7 days of treatment. This antidepressant effect was sustained for at least 5 mo as indicated by an open study phase following the double-blind study. Side effects, particularly anticholinergic properties, were significantly less apparent on trazodone compared to imipramine. A limited study of the relationship of trazodone plasma levels to therapeutic outcome revealed no simple linear relationship and represents a direction for future research. © Williams & Wilkins 1981. All Rights Reserved.