ORIGINAL ARTICLESAssociation between FOXP2 polymorphisms and schizophrenia with auditory hallucinationsSanjuán, Julioa; Tolosa, Amparob; González, José C.a; Aguilar, Eduardo J.a; Pérez-Tur, Jordic; Nájera, Carmenb; Moltó, María Doloresb; Frutos, Rosa deb Author Information aPsychiatric Unit, Faculty of Medicine, Clinical Hospital bDepartment of Genetics, Faculty of Biology, University of Valencia cInstitute of Biomedicine, CSIC, Valencia, Spain Correspondence and requests for reprints to Julio Sanjuan, Unidad de Psiquiatría, Facultad de Medicina, Universidad de Valencia, 46010 Valencia, Spain E-mail: julio.sanjuá[email protected] Sponsorship: This study was supported by Spanish grants from Red de Genotipación y Psiquiatría Genética (ISCIII 2003 – G03/184) and FIS P.I. 02/0018. Received 14 October 2005 Accepted 2 December 2005 Psychiatric Genetics: April 2006 - Volume 16 - Issue 2 - p 67-72 doi: 10.1097/01.ypg.0000185029.35558.bb Buy Metrics Abstract Objective A mutation in the FOXP2 gene has been the first genetic association with a language disorder. Language disorder is considered as a core symptom of schizophrenia. Therefore, the FOXP2 gene could be considered a good candidate gene for the vulnerability to schizophrenia. Methods A set of single nucleotide polymorphisms mainly located in the 5′ regulatory region of the FOXP2 gene was analysed in a sample of 186 DSM-IV schizophrenic patients with auditory hallucinations and in 160 healthy controls. Results Statistically significant differences in the genotype (P=0.007) and allele frequencies (P=0.0027) between schizophrenic patients with auditory hallucinations and controls were found in the single nucleotide polymorphism rs2396753. These P values changed to 0.07 and 0.0273, respectively, after Bonferroni sequential correction. The haplotype rs7803667T/rs10447760C/rs923875A/rs1358278A/rs2396753A (TCAAA) also showed a significant difference confirmed with a permutation test (P=0.009). Conclusions These results suggested that the FOXP2 gene may confer vulnerability to schizophrenic patients with auditory hallucinations. © 2006 Lippincott Williams & Wilkins, Inc.