The DRD4 gene and the spiritual transcendence scale of the character temperament index: PDF OnlyThe DRD4 gene and the spiritual transcendence scale of the character temperament indexComings, David E.a; Gonzales, Nancya; Saucier, Gerardb; Johnson, Patrick J.c; MacMurray, James P.d Author Information aDepartment of Medical Genetics, City of Hope Medical Center, Duarte, California, USA;bDepartment of Psychology, University of Oregon, Eugene, Oregon, USA;cBehavioral Medicine Service 116A, Jerry L. Pettis VAMC, Loma Linda, California, USA;dDepartment of Psychiatry, Loma Linda University School of Medicine, Loma Linda, California, USA Correspondence to David E. Comings, Department of Medical Genetics, City of Hope Medical Center, Duarte, California, USA. E-mail:[email protected] Received 30 June 2000; accepted 5 January 2001 Psychiatric Genetics: December 2000 - Volume 10 - Issue 4 - p 185-189 Buy Abstract Two hundred male subjects (81 college students and 119 subjects from an addiction treatment unit) were administered the Temperament and Character Inventory (TCI) and genotyped at the 48 base pair repeat polymorphism of theDRD4gene. Subjects were divided by genotype into those carrying any < 4 repeat allele, those homozygous for the 4 repeat allele, and those with any > 4 repeat allele. The total MANCOVA of seven TCI summary scores, with age and diagnostic group as covariates, was significant (P≤ 0.001). The largest effect was with self-transcendence (P≤ 0.001). The total MANCOVA for the three self-transcendence subscores was significant (P≤ 0.017), with the spiritual acceptance subscore showing the most effect (P≤ 0.001, power = 0.91). These results suggest theDRD4gene may play a role in the personality trait of spiritual acceptance. This may be a function of the high concentration of the dopamine D4 receptor in the cortical areas, especially the frontal cortex. © 2000 Lippincott Williams & Wilkins, Inc.