Gender differences in association between serotonin transporter gene polymorphism and personality traits: PDF OnlyGender differences in association between serotonin transporter gene polymorphism and personality traitsDu, Lisheng; Bakish, David; Hrdina, Pavel D.Author Information Institute of Mental Health Research at Royal Ottawa Hospital and University of Ottawa, Ottawa, Ontario, Canada Correspondence to Lisheng Du, IMHR at Royal Ottawa Hospital and University of Ottawa, 1145 Carling Avenue, Ottawa, Ontario, Canada K1Z 7K4. E-mail[email protected] Received 28 December 2000; accepted 2 January 2001 Psychiatric Genetics: December 2000 - Volume 10 - Issue 4 - p 159-164 Buy Abstract Since Lesch and colleagues reported an association between anxiety-related traits (Neuroticism) and a functional polymorphism in the serotonin transporter gene regulatory region (5-HTTLPR), there have been several reports on 5-HTTLPR and personality traits with both positive and negative results. The present study was a further attempt to replicate the original findings of Leschet al.in a population of well-defined normal healthy subjects. In addition, a variable number tandem repeat polymorphism in the second intron was included in this study because it has recently been shown to act as a transcriptional regulator. Personality traits were evaluated in 186 unrelated normal subjects by the NEO Five Factor Inventory. The most important and novel finding of this study was a significant association of mean Neuroticism scores with the short allele of 5-HTTLPR in male subjects (t= 2.4,P= 0.018). We were thus able to replicate the finding of Leschet al.of an association between serotonin transporter gene polymorphism (5-HTTLPR) and Neuroticism, but only in a male population. We also found a significant effect of gender on mean scores of Neuroticism [F= 3.9, degrees of freedom (df) = 1, 180,P= 0.05] and Agreeableness (F= 6.8, df = 1, 180,P= 0.01), but no significant effect of 5-HTTLPR genotype on Neuroticism (F= 0.87, df = 2, 180,P= 0.42) or Agreeableness (F= 0.35, df = 2, 180,P= 0.7). These findings suggest that gender differences exist in contribution of genetic factors to behavioural phenotypes. They may also explain the inconsistencies in previous reports on association of Neuroticism with 5-HTTLPR from studies using different proportions of male and female subjects. © 2000 Lippincott Williams & Wilkins, Inc.