Review ArticleSchizophrenia in a genomic era a review from the pathogenesis, genetic and environmental etiology to diagnosis and treatment insightsZamanpoor, Mansoura,,bAuthor Information aDepartment of Biochemistry, University of Otago, Dunedin, New Zealand and bWellington Regional Genetics Laboratory, Genetic Health Service New Zealand, Wellington Regional Hospital, Wellington, New Zealand Received 7 March 2019 Accepted 27 September 2019 Supplemental Digital Content is available for this article. Direct URL citations appear in the printed text and are provided in the HTML and PDF versions of this article on the journal's website, www.psychgenetics.com. Correspondence to Mansour Zamanpoor, Wellington Regional Genetics Laboratory, Wellington Regional Hospital, Wellington 6021, New Zealand, Tel: +6449185352; fax: +6443855822; e-mail: email@example.com Psychiatric Genetics: February 2020 - Volume 30 - Issue 1 - p 1-9 doi: 10.1097/YPG.0000000000000245 Buy SDC Metrics Abstract Schizophrenia is a common multigenic and debilitating neurological disorder characterized by chronic psychotic symptoms and psychosocial impairment. Complex interactions of genetics and environmental factors have been implicated in etiology of schizophrenia. There is no central pathophysiology mechanism, diagnostic neuropathology, or biological markers have been defined for schizophrenia. However, a number of different hypotheses including neurodevelopmental and neurochemical hypotheses have been proposed to explain the neuropathology of schizophrenia. This review provides an overview of pathogenesis, genetic and environmental etiologies to diagnosis and treatment insights in clinical management of schizophrenia in light of the recent discoveries of genetic loci associated with susceptibility to schizophrenia. Copyright © 2020 Wolters Kluwer Health, Inc. All rights reserved.