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Clinical association to FKBP5 rs1360780 in patients with depression

Dam, Henrika; Buch, Jens O.D.a; Nielsen, Annelaura B.b; Weikop, Piac; Werge, Thomasd; Jørgensen, Martin B.a

doi: 10.1097/YPG.0000000000000228
Original Articles
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The FKBP5 protein is of importance for the function of the glucocorticoid receptor. The purpose of the present study was to examine the possible association between the different genotypes of rs1360780 in the FKBP5 gene, and clinical symptoms in patients with unipolar depression. Seven hundred eighteen patients and 673 controls from the Danish Psychiatric Biobank were participated. No association was found between any genotype and diagnosis of unipolar depression. It was found that the group of depressed patients with the CC genotype showed significantly earlier start of treatment with medicine, had a significantly greater tendency to be treated with electroconvulsive therapy and showed a significantly higher frequency of family history of depression compared with the combined group of patients with the CT and TT genotypes. The only informations about controls were their sex and that they were recruited from the blood bank. The clinical data were not complete for all patients

aMental Health Center Copenhagen

bNovo Nordisk Foundation Center for Protein Research

cCenter for Translational Neuromedicine

dMental Health Center Sanct Hans, University of Copenhagen, Denmark

Received 28 December 2018 Accepted 29 April 2019

Correspondence to Henrik Dam, MD, MSc, Mental Health Center Copenhagen, University Hospital of Copenhagen, Edel Sauntes Alle 10, 2100 Copenhagen O, Denmark, Tel: +45 38 64 71 03; fax: +45 38 64 70 77; e-mail: henrik.dam@regionh.dk

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