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Decreased serum complement component 4 levels in patients with schizophrenia

Ji, Ruo-nan*,; Zhang, Li-li*,; Zhao, Meng-fei; He, Hui-fang; Bai, Wei; Duan, Rui-xin; Kou, Chang-gui

doi: 10.1097/YPG.0000000000000226
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Dysregulation of the immune system in mental disease, particularly complement component 4 (C4), which may be associated with schizophrenia, has been repeatedly observed. This study investigated the association between the level of serum component 4 and schizophrenia. Data were derived from a case-control association study of 40 unrelated adult patients with schizophrenia and 40 matched healthy controls. The component 4 level in serum was measured for comparative analysis by a component 4 enzyme-linked immunosorbent assay kit. Our findings suggest that the serum component 4 level is lower in patients with schizophrenia than in the controls, and the results apply to both males and females. Our results will lay an important foundation for establishing diagnostic methods and provide feasible and reliable evidence for the clinical treatment of schizophrenia.

Department of Epidemiology and Biostatistics, School of Public Health, Jilin University, Changchun, China

* Ruo-nan Ji and Li-li Zhang contributed equally to this article.

Received 12 October 2018 Accepted 19 March 2019

Correspondence to Chang-gui Kou, PhD, Department of Epidemiology and Biostatistics, School of Public Health, Jilin University, NO. 1163 Xinmin Street, Changchun, Jilin Province 130021, China, Tel: +86 431 85619173; fax: +86 431 85619451; e-mail: koucg@jlu.edu.cn

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