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Association of polymorphisms in HTR2A, TPH1, and TPH2 genes with attempted suicide in rural China

Pan, Yan-Feia; Zhang, Ji-Yub; Qiu, Hui-Minc; Yu, Peng-Penga; Liu, Zhen-Zhena; Liu, Bao-Penga; Jia, Cun-Xiana

doi: 10.1097/YPG.0000000000000221
Original Article
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Objective We aimed to test the association of polymorphisms in HTR2A, TPH1, and TPH2 genes with attempted suicide in rural China.

Participants and methods On the basis of a case–control study, we recruited 1200 pairs of participants from Shandong Province, China. The blood samples of 712 suicide attempters and 739 nonsuicide attempters were collected finally. We tested seven single nucleotide polymorphisms: rs6313 and rs6311 in HTR2A, rs4537731, rs1800532, and rs1799913 in TPH1, and rs4448731 and rs4641527 in TPH2.

Results In univariate analysis, allele C of rs4537731 was associated negatively with attempted suicide among total and male samples; however, the association was not statistically significant in multivariate analysis after adjusting for other potential confounding factors. No association between other six single nucleotide polymorphisms and attempted suicide was found in the total, male, or female samples.

Conclusion This study did not support the effect of these seven serotonergic gene polymorphisms on attempted suicide in rural China.

aDepartment of Epidemiology, School of Public Health, Shandong University and Shandong University Center for Suicide Prevention Research

bShandong Provincial Center for Disease Control and Prevention

cShandong Provincial Center for Mental Health, Jinan, China

Received 29 September 2018 Revised 25 December 2018

Accepted 30 January 2019

Correspondence to Cun-Xian Jia, PhD, Department of Epidemiology, School of Public Health, Shandong University and Shandong University Center for Suicide Prevention Research, No. 44, Wenhuaxi Road, Jinan 250012, China Tel: +86 531 8838 2141 x8803; fax: +86 531 8838 2553; e-mail: jiacunxian@sdu.edu.cn

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