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Schizophrenia in microcephalic osteodysplastic primordial dwarfism type II syndrome

supporting evidence for an association between the PCNT gene and schizophrenia

Ozel, Fatiha; Direk, Nesea; Ataseven Kulali, Melikeb; Giray Bozkaya, Ozlemb; Ada, Emelc; Alptekin, Koksala

doi: 10.1097/YPG.0000000000000214
BRIEF REPORT
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Schizophrenia is a genetically complex disease that is related to neurodevelopmental abnormalities. Several genetic polymorphisms and genetic syndromes associated with neurodevelopmental processes have been linked to schizophrenia. In this case report, we present a case with an association between microcephalic osteodysplastic primordial dwarfism type II and schizophrenia. Microcephalic osteodysplastic primordial dwarfism type II syndrome is a rare, autosomal recessive disease that occurs as a result of the mutations in the pericentrin (PCNT) gene that are responsible for cell cycle and division. In this report, we discuss the possible association between the PCNT gene and schizophrenia.

Departments of aPsychiatry

bPediatrics, Division of Genetics

cDepartment of Radiology, Dokuz Eylul University, Izmir, Turkey

Correspondence to Nese Direk, MD, PhD, Department of Psychiatry, Dokuz Eylul University Hospital, Inciralti Mevkii, Mithatpasa Cad. No: 1606, Balcova, 35340 Izmir, Turkey Tel: +90 532 501 0261; fax: +90 232 278 2366; e-mail: nese.direk@deu.edu.tr

Received April 23, 2018

Received in revised form November 6, 2018

Accepted November 13, 2018

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