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The effect of the polymorphisms of 5-HTTLPR on new onset of depression in patients who underwent pacemaker implantation

Xu, Haiyinga,*; Zhang, Qingb,*; Hou, Xuweia; Wang, Qingmeic; Xu, Yizhoua; Li, Lulud; Wang, Ningfua

doi: 10.1097/YPG.0000000000000012
Original Articles

Aim To study the role of serotonin transporter gene (5-HTTLPR) polymorphisms in the incidence of depression in a Chinese cohort who underwent pacemaker (PM) implantation.

Methods A total of 294 patients treated with PMs were enrolled. The 5-HTTLPR gene polymorphism was determined.

Results We found that the 5-HTTLPR SS genotype was significantly associated with the risk of depression after PM implantation (odds ratio=3.916, compared with LL carriers, P<0.001), especially in female patients and patients who are smokers. Female SS genotype carries 9.75 times higher risk for depression, and smokers with the SS genotype had 9.45 times higher risk for new onset of depression after the procedure. Pace mode had no influence on the onset of depression.

Conclusion This study suggests a significant association between the 5-HTTLPR gene polymorphism and the new onset of depression after PM implantation, especially in women or those who were smokers.

aDepartment of Cardiology, Hangzhou First Municipal Hospital and Hangzhou Hospital, Nanjing Medical University, Hangzhou

bDepartment of Cardiology, Huai’an First People’s Hospital, Nanjing Medical University, Jiangsu

cDepartment of Pediatrics, Yanzhou General Hospital, Shandong

dDepartment of Biostatistics, College of Public Health, Harbin Medical University, Heilongjiang, China

*Haiying Xu and Qing Zhang contributed equally to the writing of this article.

Correspondence to Xuwei Hou, MD, PhD, Department of Cardiology, Hangzhou First Municipal Hospital and Hangzhou Hospital, Nanjing Medical University, Huan-sha Road 261, Hangzhou 310006, China Tel: +86 571 87065701; fax: +86 571 87065702; e-mail:

Received February 3, 2013

Accepted August 8, 2013

© 2014 Wolters Kluwer Health | Lippincott Williams & Wilkins