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No association between MspI allele of the ADRA2A polymorphism and ADHD: meta-analysis of family-based studies

Shiffrin, Nina D.a; Gruber, Junea; Glatt, Stephen J.b; Faraone, Stephen V.b

doi: 10.1097/YPG.0b013e3283631509
Brief Report

There is evidence for a genetic contribution to attention-deficit hyperactivity disorder (ADHD), although no candidate genes have attained genome-wide significance to date. Given that the noradrenergic system has been implicated in ADHD, the gene for the α2-adrenergic receptor (ADRA2A) has been hypothesized to contribute to the pathogenesis of ADHD. The present investigation reports results from a meta-analysis of family-based studies that did not find a significant association between the MspI polymorphism of the ADRA2A gene and ADHD.

aDepartment of Psychology, Yale University, New Haven, Connecticut

Departments of bPsychiatry, and Neuroscience and Physiology, SUNY Upstate Medical University, Syracuse, New York, USA

Correspondence to Stephen V. Faraone, PhD, Department of Psychiatry, SUNY Upstate Medical University, 750 East Adams St., Syracuse, NY 13210, USA Tel: +1 315 464 3113; fax: +1 315 849 1839; e-mail:

Received October 4, 2012

Accepted January 14, 2013

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