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Thyroid-stimulating hormone, 5-HTTLPR genotype, and antidepressant response in depressed women

Gressier, Florencea; Trabado, Séverineb; Verstuyft, Célinec; Bouaziz, Elodiec; Hardy, Patricka; Fève, Brunod; Becquemont, Laurentc; Corruble, Emmanuellea

doi: 10.1097/YPG.0b013e3283457be5
Brief Reports

Basal serum thyroid-stimulating hormone (TSH) levels may predict antidepressant efficacy in patients with major depressive episodes (MDE), but data are inconsistent. As the SS genotype of the 5-HTTLPR polymorphism has been associated with a lower antidepressant efficacy in women with MDE, we aimed at assessing the relationship between normal basal TSH, 5-HTTLPR, and antidepressant efficacy in women. A total of 71 women and 28 men, with normal baseline TSH serum levels, hospitalized for a MDE, were assessed for 5-HTTLPR genotypes and prospectively followed for short-term antidepressant efficacy. Women with SS genotype had higher TSH levels (P=0.002) and a worse antidepressant response (P=0.046) than the women with LL/LS genotype, whereas no significant difference was shown in men. In multivariate analyses, antidepressant response in women was explained by TSH and 5-HTTLPR, but not by other variables. Further research is needed to understand the underlying mechanism explaining interactions between sex, TSH, and serotonergic function.

aDepartment of Psychiatry, INSERM U669

bLaboratory of Molecular Genetics, Pharmacogenetics and Hormonology, INSERM U693

cLaboratory of Molecular Genetics, Pharmacogenetics and Hormonology, Department of Pharmacology

dDepartment of Endocrinology, INSERM U693, Univ Paris Sud, Assistance Publique-Hôpitaux de Paris, Bicêtre University Hospital, Le Kremlin Bicêtre, France

Correspondence to Florence Gressier, MD, Department of Psychiatry, Univ Paris Sud, Assistance Publique-Hôpitaux de Paris, Bicêtre University Hospital, 78 rue du Général Leclerc, Le Kremlin Bicêtre 94275, France Tel: +33 14 5212524; fax: +33 14 5212864; e-mail:

Received April 26, 2010

Accepted December 9, 2010

© 2011 Lippincott Williams & Wilkins, Inc.