A recent study in a sample of Plains Indians showed association between eight single nucleotide polymorphisms (SNPs) located in the SGIP1 gene and resting θ electroencephalogram (EEG) power. This association appeared to generalize to alcohol use disorders, for which EEG power is a potential endophenotype. We analyzed a large, diverse sample for replication of the association of these implicated SGIP1 SNPs (genotyped on the Illumina 1M platform) with alcohol dependence (N=3988) and θ EEG power (N=1066). We found no evidence of association of the earlier implicated SGIP1 SNPs with either alcohol dependence or θ EEG power (all P>0.15) in this sample. The earlier implicated SNPs located in SGIP1 gene showed no association with alcohol dependence or θ EEG power in this sample of individuals with European and/or African ancestry. This failure to replicate may be the result of differences in ancestry between this sample and the original sample.
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aDepartment of Psychology, University of Minnesota, Minneapolis, Minnesota
bSUNY Downstate Medical Center, Brooklyn, New York
cSouthwest Foundation for Biomedical Research, Texas
dNational Human Genome Research Institute, Bethesda, Maryland
eIndiana University, Indiana
fUniversity of Iowa, Iowa
gRutgers University, New Jersey
hWashington University in Saint Louis, Saint Louis, Missouri, USA
Correspondence to Jaime Derringer, MA, Department of Psychology, University of Minnesota, N218 Elliott Hall, 75 E River Rd, Minneapolis, MN 55455, USA Tel: +1 612 412 1107; fax: +1 612 825 6280; e-mail: firstname.lastname@example.org
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Received August 2, 2010
Accepted November 23, 2010