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No NRG1 V266L in Chinese patients with schizophrenia

Garcia-Barceló, Maria-Mercèd; Miao, Xiaopingd,g; Tang, Clara S.a; So, Hon-Cheonga; Tang, Waikiud; Leon, Thomas Y.Y.d; So, Mantingd; Yip, Benjamina,d; Chen, Ronald Y.L.a; Cheung, Eric F.C.e; Chen, Eric Y.H.f; Li, Taof,h; Tam, Pauld; Cherny, Stacey S.a,c; Sham, Pak C.a,b,c

doi: 10.1097/YPG.0b013e328341355b
Brief Report

NRG1 is one of the best-supported schizophrenia (SZ) susceptibility genes. A NRG1 V266L missense mutation has been found to be associated with SZ in several populations. V266L is not in linkage disequilibrium with any of the SZ-associated NRG1 haplotypes described thus far, and may represent an independent SZ susceptibility locus within NRG1 gene. V266 is a highly conserved residue and its substitution is predicted to have a deleterious effect on the protein. As there are no data for V266L in Chinese, and given the potential relevance of this mutation, we investigated the V266L prevalence in 270 Chinese patients with schizophrenia and 270 ethnically matched controls. V266L was found neither in patients nor in controls. Lack of replication of an association across populations may be because of the differences in linkage disequilibrium structure or allele frequencies. Some true associations may not be replicated regardless of the sample size of the study.

aDepartment of Psychiatry

bGenome Research Centre

cState Key Laboratory of Brain and Cognitive Sciences

dDepartment of Surgery of the Li Ka-shing, Faculty of Medicine, University of Hong Kong

eCastle Peak Hospital, Hong Kong SAR

fInstitute of Mental Health, West China Hospital, West China Medical School of Sichuan University, Chengdu

gDepartment of Epidemiology and Biostatistics, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China

hDivision of Psychological Medicine and SGDP Centre, Institute of Psychiatry, King's College, London

Correspondence to Professor Pak C. Sham, Department of Psychiatry, Li Ka-shing Faculty of Medicine, The University of Hong Kong, Hong Kong, Sar, China Tel: +852 2819 9557; fax: +852 2855 1345; e-mail:

Received February 10, 2010

Accepted May 13, 2010

© 2011 Lippincott Williams & Wilkins, Inc.