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Habituation in prepulse inhibition is affected by a polymorphism on the NMDA receptor 2B subunit gene (GRIN2B)

Hokyo, Akiraa b; Kanazawa, Tetsufumia b; Uenishi, Hiroyukib c; Tsutsumi, Atsushia f; Kawashige, Seiyaa g; Kikuyama, Hirokia e; Glatt, Stephen J.i; Koh, Juna; Nishimoto, Yoshiyukia b; Matsumura, Hitoshih; Motomura, Naoyasua d; Yoneda, Hiroshia

doi: 10.1097/YPG.0b013e32833a201d
Original Articles

Objectives To identify the reliable connectivity between causal genes or variants with an abnormality expressed in a certain endophenotype has been viewed as a crucial step in unraveling the etiology of schizophrenia because of the considerable heterogeneity in this disorder.

Methods According to this practical and scientific demand, we aimed to investigate the relationship between seven top-ranked variants in the SZgene database [120-bpTR in DRD4, rs1801028 and rs6277 in DRD2, rs1019385 (T200G) in GRIN2B, rs1800532 in TPH1, rs1801133 (C677T) in MTHFR, rs2619528 (P1765) in DTNBP1] and prepulse inhibition (PPI) and habituation after acoustic stimulus (HAB).

Results Both PPI and HAB were decreased significantly in patients with schizophrenia. In addition, we observed a significant effect of GRIN2B (human NMDA receptor 2B subunit gene, NR2B) genotype on HAB (P<0.05, not corrected).

Conclusion Although these findings need to be replicated in other samples, an underlying mechanism of impaired biological reaction may be influenced by NMDA hypofunctioning in schizophrenia.

aDepartment of Neuropsychiatry, Osaka Medical College, Takatsuki

bOzone Hospital, Toyonaka

cGraduate School of Letters, Kansai University

dOsaka Kyoiku University

eShin-Abuyama Hospital

fAino Hanazono Hospital

gShin-Awaji Hospital, Osaka

hLaboratory of Pharmacotherapy, Osaka University of Pharmaceutical Sciences, Osaka, Japan

iDepartment of Psychiatry and Behavioral Sciences, Medical Genetics Research Center (MGRC), SUNY Upstate Medical University, USA

Correspondence to Tetsufumi Kanazawa, MD, PhD, Department of Neuropsychiatry, Osaka Medical College, 2-7 Daigaku-machi Takatsuki-City, Osaka 569-0801, Japan

Tel: +81 72 6831221; fax: +81 72 6834810;


Received 19 May 2009 Revised 18 November 2009 Accepted 1 January 2010

© 2010 Lippincott Williams & Wilkins, Inc.